A5101404794- Microbial Natural Products and Biosynthesis
- Kruppel-like factors research
- Marine Sponges and Natural Products
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cryospheric studies and observations
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Chronic Myeloid Leukemia Treatments
- Climate change and permafrost
- Cardiovascular Disease and Adiposity
- Fungal Biology and Applications
- Acute Myocardial Infarction Research
- Neurological Disease Mechanisms and Treatments
- Spinal Fractures and Fixation Techniques
- Autophagy in Disease and Therapy
- Plant-Microbe Interactions and Immunity
- Endoplasmic Reticulum Stress and Disease
- Plant Pathogens and Fungal Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Management of metastatic bone disease
- Protein Hydrolysis and Bioactive Peptides
- Mycotoxins in Agriculture and Food
- Protein Kinase Regulation and GTPase Signaling
- Studies on Chitinases and Chitosanases
Chinese Academy of Sciences
2008-2025
Northwest Institute of Eco-Environment and Resources
2020-2025
Tibet Autonomous Region People's Hospital
2025
Chongqing Medical University
2023-2024
Xuzhou Medical College
2021-2024
Institute of Tibetan Plateau Research
2024
Central Hospital of Zibo
2019-2024
Weifang Medical University
2024
Soochow University
2023
Wuxi Ninth People's Hospital
2023
Abstract. The Tibetan Plateau (TP) plays a critical role in influencing regional and global climate, via both thermal dynamical mechanisms. Meanwhile, as the largest high-elevation part of cryosphere outside polar regions, with vast areas mountain glaciers, permafrost seasonally frozen ground, TP is characterized an area sensitive to climate change. However, meteorological stations are biased sparsely distributed over TP, owing harsh environmental conditions, high elevations, complex...
Pathogenic bacterial infection and poor native tissue integration are two major issues encountered by biomaterial implants devices, which extremely hard to overcome within a single surface, especially for those without involvement of antibiotics. Herein, self-adaptive surface that can transform from non-antibiotic antibacterial actions promotion cell proliferation is developed in situ assembly bacteriostatic 3,3′-diaminodipropylamine (DADP)-doped zeolitic imidazolate framework-8 (ZIF-8) on...
The interaction between endoplasmic reticulum (ER) and mitochondria has been shown to play a key role in hepatic steatosis during chronic obesity. β-nicotinamide mononucleotide (NMN) reported regulate obesity, however, its molecular mechanism at the subcellular level remains unclear. Here, NMN improved liver insulin resistance high-fat diet (HFD) mice. RNA-seq showed that compared with of HFD mice, intervention enhanced fat digestion absorption stimulated cholesterol metabolism signaling...
Strain 12A35 was isolated from a deep-sea sediment collected the South China Sea and showed promising antibacterial activities. It identified as Streptomyces sp. by 16S rDNA sequence analysis. Bioassay-guided fractionation using HP20 adsorption, flash chromatography over silica gel octadecylsilyl (ODS) semi-preparative HPLC, led to isolation purification of five metabolites fermentation culture 12A35. Two new spirotetronate antibiotics, lobophorins H (1) I (2), along with three known...
The SNP of rs964184 in ZPR1 has recently been associated with type 2 diabetes mellitus (T2DM) Japanese individuals. To comprehensively investigate the association common variants T2DM Han Chinese individuals, we designed a two-stage case-control study 3,505 patients and 6,911 unrelated healthy A total 24 single nucleotide polymorphisms (SNPs) were genotyped, single-SNP association, imputation gender-specific analyses performed. increase coverage genetic markers, implemented techniques to...
Abstract Adiponectin (APN) deficiency has also been associated with Alzheimer‐like pathologies. Recent studies have illuminated the importance of APN signaling in reducing Aβ accumulation, and elimination mechanism remains rudimentary. Therefore, we aimed to elucidate role accumulation its abnormalities by targeting autophagy lysosomal protein changes. To assess, performed a combined pharmacological genetic approach while using preclinical models human samples. Our results demonstrated that...
To evaluate the influence of various distributions bone cement on clinical efficacy percutaneous kyphoplasty (PKP) in treating osteoporotic vertebrae compression fractures.A total 201 OVCF patients (30 males and 171 females) who received PKP treatment our hospital were enrolled this study. According to characteristic distribution, divided into 2 groups: group A ("H" shaped group), filling pattern vertebral body briquettes connected with / without bridge; B ("O" was a complete crumb any...
Abstract In a stable boundary layer (SBL), turbulence is generally weak and exhibits significant intermittent characteristics. Interactions among motions of different scales complicate its structural evolution, making prediction challenging. This study focuses on two typical processes in the SBL: low‐level jet (LLJ) internal gravity waves (IGWs), investigating how their interactions influence evolution structures. Utilizing full observation network data processing system at Zhongchuan...
A comparison of evapotranspiration between seasonally frozen and permafrost soils has important theoretical value for studying land surface processes ecological environmental evolution on the Tibetan Plateau. In this work, actual (ETa) reference (ET0) crop coefficient (Kc) were calculated via eddy covariance data meteorological gradient from sites in Naqu Prefecture Tanggula Mountains. The variations, differences, factors influencing ETa ET0 analysed. results revealed that at two 2008,...
Chemerin, an adipocyte-secreted protein, has been recently suggested to be linked metabolic syndrome and cardiac function in obese diabetes mellitus. This study aimed investigate the potential roles of adipokine chemerin on high fat-induced dysfunction. Chemerin (Rarres2) knockout mice, which were fed with either a normal diet or high-fat for 20 weeks, employed observe whether affected lipid metabolism, inflammation, function. Firstly, we found substrate inflexibility Rarres2−/− mice diet....
Abstract A new dibenzo[1,4]dioxin 1 , and two prenylated diphenyl ethers, 2 3 together with six known compounds, 4 – 9 were isolated from a sponge‐associated fungus Aspergillus versicolor Hmp‐F48 by bioactivity‐guided fractionation. Their structures elucidated 1D‐ 2D‐NMR, MS analyses. The compounds showed potent cell growth inhibitory activities against HL‐60 line.
Abstract Background Role of plasma vitamin D and genetic variants its receptor (VDR) in susceptibility to different diseases has been documented. Various studies populations have highlighted strong associations with diabetes cardiovascular diseases. Vitamin deficiency linked the development type 2 (T2D) onset coronary artery (CAD). However, role predisposition CAD patients T2D is ill‐defined. Materials Methods We enrolled 674 Chinese patients, based on clinical phenotype, were further...
To investigate any associations between blood glucose (BG) and lipid levels in patients with different tolerance statuses, including type 2 diabetes (T2DM) impaired regulation (IGR) cases as well normal (NGT) individuals.A total of 354 participants were recruited to this study 174 the T2DM group, 112 IGR group 68 NGT group. We compared BG, insulin C-peptide (CP), cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C) low-density (LDL-C) serum during a 3 h oral test (OGTT)...
Activity-guided fractionation of a methanol extract from the culture broth Myrothecium verrucaria Hmp-F73, fungus associated with sponge Hymeniacidon perleve, afforded six macrocyclic trichothecenes, verrucarin J (1), 8-hydroxyverrucarin (2), A (3), 8-acetoxyroridin H (4), isororidin E (5), and roridin (6), along trichoverrin B (7). All seven metabolites displayed potent toxicity to brine shrimp ( Artemia salina). In addition, compounds 2, 3, 6 showed weak phytotoxic activities against...
Diabetes associated injury healing and other tissue irregularities are viewed as a significant concern. The purpose of the study is to design wound regeneration activity Ficus carica extract (FFE) loaded amphiphilic polymeric scaffold poly(xylitol-g-adipate-co-glutamide) (PXAG)–polyhydroxybutyrate (PHB) for potential diabetic affected regeneration. PXAG copolymer was prepared by condensation method, scaffolds PXAG-PHB, PXAG-PHB/FFE were developed through ultra-sonication process magnetic...
Background Recently, NUS1 and GP2 genes were reported to be associated with the risk of type 2 diabetes (T2D) in a Japanese population. Given sharing pathogenic contribution from genetic factors between T2D gestational mellitus (GDM), we conducted study systematically examine relationship susceptibility GDM Chinese Han Methods A total 4,250 subjects comprised 1,282 patients 2,968 controls recruited, 20 tag single nucleotide polymorphisms (SNPs) (10 10 ) selected for genotyping. Association...
Background: Neuroendocrine carcinoma is rare with a proportion of less than 2% in gallbladder malignancies, cases neuroendocrine cell coexisting adenocarcinoma are exceptionally rare, and the prognosis dismal. Methods: Herein, we presented an unusual case poorly differentiated who survived 20 months after multimodal treatment (MT) extended surgery postoperative chemotherapy. Results: Our result indicated that for advanced adenocarcinoma, MT including surgical approach combined chemotherapy...
To investigate the effects of down-regulation p21 activated kinase 1 (PAK1) on proliferation, differentiation, and apoptosis myeloproliferative neoplasm (MPN) cells (6133/MPL) with thrombopoietin receptor MPL mutation at codon 515 (