A5101964577- Sperm and Testicular Function
- Advanced biosensing and bioanalysis techniques
- Heavy metals in environment
- Mycotoxins in Agriculture and Food
- Hormonal and reproductive studies
- Ecology and Vegetation Dynamics Studies
- Animal Nutrition and Physiology
- Blood properties and coagulation
- Tracheal and airway disorders
- Biosensors and Analytical Detection
- Carbon and Quantum Dots Applications
- Environmental and Agricultural Sciences
- Nanoplatforms for cancer theranostics
- Flood Risk Assessment and Management
- Extraction and Separation Processes
- Plant Pathogens and Fungal Diseases
- Plant Toxicity and Pharmacological Properties
- RNA Interference and Gene Delivery
- Analytical chemistry methods development
- Remote Sensing and Land Use
- Selenium in Biological Systems
- Land Use and Ecosystem Services
- Quantum Dots Synthesis And Properties
- Antiplatelet Therapy and Cardiovascular Diseases
- Metal Extraction and Bioleaching
First Affiliated Hospital of Henan University of Science and Technology
2024
China Geological Survey
2024
Henan University of Science and Technology
2011-2024
First Affiliated Hospital of Chengdu Medical College
2023-2024
Chengdu Medical College
2024
Chengdu University of Traditional Chinese Medicine
2023
Beijing Forestry University
2014-2023
Guangxi Medical University
2023
West China Second University Hospital of Sichuan University
2022
Peking University
2022
Under normal physiological conditions, reactive oxygen species (ROS) are produced through redox reactions as byproducts of respiratory and metabolic activities. However, due to various endogenous exogenous factors, the body may produce excessive ROS, which leads oxidative stress (OS). Numerous studies have shown that OS causes a variety pathological changes in cells, including mitochondrial dysfunction, DNA damage, telomere shortening, lipid peroxidation, protein modification, all can...
Heavy metal contamination of mine tailings is one the most serious environmental challenges facing mining industry worldwide. Conventional technologies used for treatment such tailing soils are expensive both in terms operation and capital costs as well being not so effective. In present study, an indigenous calcifying urease producing bacterial strain was isolated from copper soil bioimmobilization copper, lead cadmium contaminated soils. Phylogenetic analysis 16S rRNA gene sequence...
The interaction between endoplasmic reticulum (ER) and mitochondria has been shown to play a key role in hepatic steatosis during chronic obesity. β-nicotinamide mononucleotide (NMN) reported regulate obesity, however, its molecular mechanism at the subcellular level remains unclear. Here, NMN improved liver insulin resistance high-fat diet (HFD) mice. RNA-seq showed that compared with of HFD mice, intervention enhanced fat digestion absorption stimulated cholesterol metabolism signaling...
Intelligent stimulus-responsive theranostic systems capable of specifically sensing low-abundance tumor-related biomarkers and efficiently killing tumors remain a pressing endeavor. Here, we report multifunctional framework nucleic acid (FNA) nanosystem for simultaneous imaging microRNA-21 (miR-21) combined chemo/gene therapy. To achieve this, two FNA nanoarchitectures labeled with Cy5/BHQ2 signal tags were designed, each which contained an AS1411 aptamer, pairs DNA/RNA hybrids, pH-sensitive...
The present study was conducted to evaluate the effects of T-2 toxin on semen quality, fertility and serum testosterone concentration in mice. Adult male mice were mated with sexually mature untreated female after being exposed intraperitoneal injection at 0, 5, 10 or 15 mg/kg body weight daily for 7 successive days. Semen treated assessed. results showed that number abnormal spermatozoa increased significantly a significant decrease integrated acrosome observed males all doses, As well,...
To explore the toxic effect of T-2 toxin on mouse Leydig cells and its underlying molecular mechanisms, we isolated from mature mice, set-up culture, treated with toxin, evaluated cell proliferation, detected caspase-3 activity, mitochondrial activity apoptosis rate, measured mRNA levels Bcl-2, Bax, PARP caspase-3. inhibited proliferation at concentrations higher than 10-9 M or time more 12 h, also decreased Bcl-2 expression M. While, increased expressions Bax 10-8 M, respectively, triggered...
Objective: To investigate the effects of T-2 toxin on testosterone biosynthesis in mouse Leydig cells. Methods: cells isolated from clean and healthy Kunming male mice, whose concentration was adjusted to 5 × 10 /mL purity identified by modified 3β-hydroxysteroid dehydrogenase staining method, were used establish a primary cell culture model. Blank control group (treated with 0 ng/mL human chorionic gonadotropin (hCG) mol/L toxin), inductive hCG low-dose T-2-toxin-exposure −9 middle-dose...
To explore the toxic mechanism of T-2 toxin on Leydig cells mice, we would investigate toxicity and oxidative stress induced by in cells. were isolated cultured with control or (10-7 M, 10-8 10-9 M) for 24 h, then supernatants harvested to examine cell viability, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) catalase (CAT) activities, expression messenger RNA (mRNA) related stress, malondialdehyde (MDA) content DNA damage. The viability was evaluated mouse MTT assay, MDA SOD,...
Abstract To explore the protective mechanism of l ‐arginine against T‐2 toxin–induced oxidative damage in mouse Leydig cells, cells were isolated and cultured with control, toxin (10 nM), (0.25, 0.5, 1.0 mM), nM toxin) or mM) for 24 hours. Cells supernatants harvested to examine cell viability, activities, messenger RNA (mRNA) expression glutathione peroxidase (GSH‐Px), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) content, DNA damage. Results showed that significantly...
Climate change will have important implications in water shore regions, such as Huang-Huai-Hai (3H) plain, where expected warmer and drier conditions might augment crop demand. Sensitivity analysis is understanding the relative importance of climatic variables to variation reference evapotranspiration (ET0). In this study, 51-yr ET0 during winter wheat summer maize growing season were calculated from a data set daily climate 40 meteorological stations. maps for key estimated according...
Abstract β‐Nicotinamide mononucleotide (NMN) is a biologically active nucleotide that regulates the physiological metabolism of body by rapidly increasing nicotinamide adenine dinucleotide (NAD + ). To determine safety and biological activity NMN resources, we constructed recombinant strain P. pastoris heterologously expresses nicotinamide‐phosphate ribosyltransferase (NAMPT), subsequently catalyzed purified expressed product to obtain NMN. Consequently, this study established high‐fat diet...