Maintaining the high activity of an enzyme is a fundamental requirement to widen application metal–organic frameworks (MOFs) in biotechnology, biosensor, and biomedicine fields. However, it still challenging monitor understand MOF environment-related for enzyme. Here, we developed MOFs-in-nanochannels configuration broadening biocatalytic MOFs on demand. ZIF-8 [Zn(mim)2, Hmim = 2-methylimidazolated] grown TiO2 nanochannels used as platform, cytochrome C (CytC) model encapsulated ZIF-8. The...

Heavy metal contamination of mine tailings is one the most serious environmental challenges facing mining industry worldwide. Conventional technologies used for treatment such tailing soils are expensive both in terms operation and capital costs as well being not so effective. In present study, an indigenous calcifying urease producing bacterial strain was isolated from copper soil bioimmobilization copper, lead cadmium contaminated soils. Phylogenetic analysis 16S rRNA gene sequence...

Hydrogen sulfide (H2S) is an extremely hazardous gas and harmful to human health the environment. Here, we developed a flexible H2S gas-sensing device operated at room temperature (25 °C) based on CuO nanoparticles coated with free-standing TiO2-nanochannel membranes that were prepared by simple electrochemical anodization. Benefiting from modulated conductivity of CuO/TiO2 p–n heterojunction unique nanochannel architecture, traditional thermal energy was innovatively replaced UV irradiation...

As a marker molecule in respiratory gases for the pulmonary disease asthma, nitric oxide (NO) has attracted much attention real-time gas monitoring. However, low sensitivity, poor selectivity, and high operating temperature limit practical applications of metal semiconductor (MOS) based chemiresistor sensors. Herein, by deliberately introducing metal-organic frameworks (MOFs) free-standing TiO2 nanochannels (NCs), sensor with excellent detection ability outstanding selective traits is...

Skin infections are major threats to human health, causing ∼500 incidences per 10 000 person-year. In patients with diabetes mellitus, particularly, skin often accompanied by a slow healing process, amputation, and even death. Timely diagnosis of infection strains on-site therapy vital in health safety. Herein, double-layered "test-to-treat" pad is developed for the visual monitoring selective treatment drug-sensitive (DS)/drug-resistant (DR) bacterial infections. The inner layer (using...

As a biomarker of periodontitis, sensitive and timely monitoring hydrogen sulfide (H2S) in exhaled breath at room temperature (RT) is important for the early intervention oral diseases. However, required high operation to achieve sensitivity still technical challenge directly breath. In this study, by integrating metal-organic frameworks (MOFs) into self-aligned TiO2 nanotube arrays (NTs), chemiresistor gas sensor with outstanding selectivity was constructed detection H2S RT. The precise...

Exhaled breath is considered an important source of samples and a reservoir biomarkers, especially for disease diagnosis. In this study, we developed ultrasensitive point-of-care gas sensor the analysis hydrogen sulfide (H2S), which typical biomarker periodontitis. A high-performance metal oxide semiconductor (MOS)-based chemiresistive H2S was by integrating Fe-doped MoO3-x onto TiO2 nanotube arrays. The substitution Fe atoms into not only induced oxygen vacancies, but also generated defect...

Phosphate (Pi) plays important roles in various physiological processes. Its quantification biological fluids is highly crucial for timely warning of Pi accumulation. Herein, an europium (Eu)-based coordination polymer nanoprobe (Eu/DPA/Ade) prepared by coordinating 2,6-pyridinedicarboxylic acid (2,6-DPA) and adenine (Ade) with Eu3+. Eu/DPA/Ade exhibits light-up fluorescence response to Pi. The strong interaction between Eu3+ O atoms the group not only shortens Eu3+-ligand distance improve...

A photocatalysis-enzyme coupled system represents a most promising approach towards artificial photosynthesis and direct use of solar energy for the synthesis specific organic molecules or fuel.

Enantioselective identification of chiral molecules is important for biomedical and pharmaceutical research. However, owing to identical molecular formulas chemical properties enantiomers, signal transduction amplification are still the two major challenges in sensing. In this study, we developed an enantioselective membrane by integrating homochiral metal–organic frameworks (MOFs) with nanochannels sensitive quantification compounds. The was designed using a TiO2 nanochannel (TiNM) as metal...

As a highly oxygen-dependent process, the effect of photodynamic therapy is often obstructed by premature leakage photosensitizers and lack oxygen in hypoxic cancer cells. To overcome these limitations, this study designs bovine serum albumin protein (BSA)-encapsulated Pt nanoclusters (PtBSA) as O2-supplied biocoats further incorporates them with mesoporous silica nanospheres to develop intelligent nanoaggregates for achieving improved therapeutic outcomes against tumors. The large number...

The combination of gold nanoclusters (AuNCs) and nanomaterial-based quencher creates an innovative method for sensors design. In this work, we report a fluorescent sensing platform sensitive detection butyrylcholinesterase (BChE). fluorescence AuNCs can be quenched by iron oxyhydroxide (FeOOH) nanomaterials. the presence BChE acetylthiocholine (ATCh), nano-FeOOH effectively decomposed enzymatic hydrolysate (thiocholine), leading to recovery fluorescence. Au/FeOOH exhibits highest quenching...

Capture, analysis, and inactivation of circulating tumor cells (CTCs) have emerged as important issues for the early diagnosis therapy cancer. In this study, an all-in-one sensing device was developed by integrating magnetic metal-organic framework (magMOF) nanoparticles (NPs) TiO2 nanotube arrays (TiNTs). The magMOF NPs are composed a Fe3O4 core MIL-100(Fe) shell, which is loaded with glucose oxidase (GOD) provides intensive starvation catalyzing consumption cellular nutrients, thus...

The level of hydrogen sulfide in the brain and vasculature has long been associated with human health diseases. Hence, simple robust analytical tools allowing determination levels are highly desirable. In this work, a biomineralization-driven ion gate TiO2 nanochannel arrays for H2S sensing was designed developed. formed CuS precipitation decreased transmembrane current presence bovine serum albumin used as biological mineralizer. Label-free assay intracellular S2- achieved based on changes...

Steam generation via harvesting solar energy is one of the promising approaches for seawater desalination. Nowadays, organic contamination in represents a great challenge that needs to be solved. Specially, low-molecular-weight molecules may easily pass through distillation membranes with water steam and enter freshwater sources. In this study, we develop membrane (DM) contaminated desalination rather than grading treatment by integrating large-scale TiO2 nanochannel plasmonic silver...

As one of the significant intracellular signaling molecules, hydrogen peroxide (H2O2) regulates some vital biological processes. However, it remains a challenge to develop noninvasive electrodes that can be used for sensing trace H2O2 at cellular level. Here, we evaluated high-performance solid-state electrochemiluminescence (ECL) sensor based on MIL-88B(Fe) nanocrystal-anchored Ti microwires. Semiconducting TiO2 nanotubes (TiNTs) vertically grown around wire via an anodization technique act...