A5048658506- Platelet Disorders and Treatments
- Schizophrenia research and treatment
- Mental Health Treatment and Access
- Hemoglobinopathies and Related Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- Acute Myeloid Leukemia Research
- Digital Mental Health Interventions
- Blood Coagulation and Thrombosis Mechanisms
- Erythrocyte Function and Pathophysiology
- Diabetes Treatment and Management
- Bone and Joint Diseases
- Diabetic Foot Ulcer Assessment and Management
- Nicotinic Acetylcholine Receptors Study
- Healthcare cost, quality, practices
- Blood disorders and treatments
- Aging and Gerontology Research
- Ion Transport and Channel Regulation
- Blood groups and transfusion
- Healthcare Decision-Making and Restraints
- Body Composition Measurement Techniques
- Inflammatory Biomarkers in Disease Prognosis
- Marriage and Sexual Relationships
- Smoking Behavior and Cessation
- Sexual function and dysfunction studies
Swansea University
1989-2023
University of Wales
1992-2009
Cardiff University
2002-2006
Cardiff and Vale University Health Board
2001
Somerset Hospital
1999
University Hospital of Wales
1994-1996
Institute of Psychiatry and Neurology
1996
Pearson (United States)
1995
Psychiatry Research Trust
1994
<h3>BACKGROUND</h3> Pulmonary rehabilitation programmes improve the health of patients disabled by lung disease but their cost effectiveness is unproved. We undertook a cost/utility analysis in conjunction with randomised controlled clinical trial pulmonary versus standard care. <h3>METHODS</h3> Two hundred patients, mainly chronic obstructive disease, were randomly assigned to either an 18 visit, 6 week programme or medical management. The difference between mean 12 months care for and...
<h3>Abstract</h3> <b>Objective</b>: To compare the risk of detention under Mental Health Act 1983 in a representative group people with psychotic disorders from different ethnic groups. <b>Setting</b>: Two defined geographical areas south London. <b>Design</b>: Annual period prevalent cases psychosis were identified 1993 study hospital and community data. Standardised criteria applied to case notes establish diagnosis act. <b>Subjects</b>: 535 patients identified, whom 439 fulfilled ICD-10...
The case records of 13 patients (24 pregnancies) with von Willebrand's disease (vWD) were studies rettospectively. overall incidence primary and secondary post-partum haemorrhage (PPH) was 15.8% 25% respectively, all PPH occurring in tyre 2 discase (3/14 deliveries, 21.4%). risk type who did not receive prophylactic factor VIII 37.5% (3/8 deliveries). Factor coagulant activity (VIII:C) Willebrand antigen (vWF:Ag) rose above bascline values by a at least 1.5 during the pregnancy most case....
Erythroid regeneration is an important and separate element in the engraftment process allogeneic autologous bone marrow transplantation (alloBMT, autoBMT). Qualitative visual reticulocyte counting has proved inadequate evaluation of erythropoiesis after BMT but automated flow cytometry now allows reliable quantitation reticulocytes even to very low levels. Reticulocyte counts highly fluorescent (HFR) (very early reticulocytes) were estimated daily recipients 22 autoBMT 14 alloBMT using a...
We had the unique opportunity to study effects of transdermal nicotine on markers haemostasis and serum lipids in patients with ulcerative colitis; all were non-smokers given assess its value maintenance therapy for colitis. In a controlled double-blind trial, 45 colitis remission 5-aminosalicylic acid, randomly allocated receive (20) or placebo (25) patches. Markers haemostasis, including platelet activation (platelet volume surface expression P selectin), endothelial damage (plasma von...
Several observations suggest that inherited factors are influential in the development of nephropathy patients with insulin-dependent diabetes mellitus (IDDM). Genetic components renin angiotensin system possible candidate genes. The aim this study was to determine role hypertension associated II type 1 receptor (AT1R) gene A1166C polymorphism susceptibility IDDM. We examined 264 Caucasoid IDDM and overt (as defined by persistent proteinuria absence other causes, retinopathy), 136 long...
Peroxisome proliferator activated receptor‐gamma is an important factor in adipocyte differentiation and energy metabolism thus a candidate gene for obesity, insulin resistance dyslipidaemia. We therefore assessed the associations between most common variant of PPAR‐γ, Pro12Ala (P12A) substitution PPAR‐γ 2 gene, with BMI, blood pressure, fasting plasma glucose, HbA 1c , total cholesterol, LDL HDL cholesterol triglyceride 183 treatment‐naïve patients type diabetes (T2D). The P12A allele...
Abstract Background Erectile dysfunction (ED) is one complication of diabetes for which the treatment rationed. Despite considerable public debate there has been no formal assessment views patients and sufferers priority treating ED. Aims To determine perceptions diabetic relative ED in comparison with treatments other complications common medical conditions. Methods Psychological measures were used to assess subjects’ importance eight problems (blindness, foot ulcers, high blood pressure,...
We describe a case of reactive haemophagocytic syndrome (RHS) in patient with previous polyarticular juvenile chronic arthritis (JCA). This is the first reported association these conditions and may be indicative defective immunological responses to viral infections this form JCA.
Background: Debates surrounding the use of conventional approaches in public health and existence perceived barriers to using results economic evaluations have led questions posed as how establish priorities within schemes. The aims this study were therefore explore feasibility validity evaluation techniques developing programmes consider extent which different presentational are likely be incorporated into decision-making, from perspectives relevant stakeholders. Methods: An advisory board,...
Thrombin and plasmin activation markers were serially measured in 80 patients undergoing bone marrow transplantation (BMT). There prothrombotic fibrinolytic responses observed during autograft allograft BMTs. Thrombin–antithrombin prothrombin fragment F1 + 2 levels increased from day −7 to −3 ( P < 0.0001) 3.7 7 ng/ml 1.2 1.63 nmol/l, respectively. A rise plasmin–antiplasmin occurred between days 4 14 0.0004), 393 on a peak of 795 11. No correlation reduced protein C post‐BMT state was observed.
This work proposes a novel combination of behavioural-tracking sensors and immersive virtual reality in gamified proof-of-concept prototype, which demonstrates affective treatment concepts for hypervigilance symptoms. A number limitations have been identified current approaches, prompting more advanced techniques that efficiently target at an individual patient level. In response, we developed first-person shooter responds to inertial user behaviour way aims combat detrimental symptoms,...
This research proposes a novel combination of behavioural-tracking sensors and immersive virtual reality in alleviating chronic loneliness. Various limitations have been identified current approaches, prompting more advanced techniques that efficiently target loneliness at an individual patient level. An affective intelligence approach has proposed to maximise cognitive behavioural therapy outcomes treatment, combining technology is successful related work.
A 19-year-old Caucasian male presented acutely describing several episodes of profound paralysis. At the time admission he had recovered completely and his neurological examination routine biochemistry were normal. diagnosis thyrotoxic periodic paralysis was made after thyroid function tests returned confirming hyperthyroidism. He given β blockers received a block replacement regime before proceeding on to radioactive iodine therapy. suffered relapse hyperthyroidism following radioiodine...