A5095764492- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
Democritus University of Thrace
2024
Circulating cell-free DNA (ccfDNA) of mitochondrial origin (ccf-mtDNA) consists a minor fraction total ccfDNA in blood or other biological fluids. Aberrant levels ccf-mtDNA have been observed many pathologies. Here, we introduce simple and effective standardized Taqman probe-based dual-qPCR assay for the simultaneous detection relative quantification nuclear fragments ccfDNA. Three pathologies major burden, one malignancy (Breast Cancer, BrCa), inflammatory (Osteoarthritis, OA) metabolic...
Abstract Schizophrenia (SCZ) is a chronic, severe, and complex psychiatric disorder that affects all aspects of personal functioning. While SCZ has very strong biological component, there are still no objective diagnostic tests. Lately, special attention been given to epigenetic biomarkers in SCZ. In this study, we introduce three-step, automated machine learning (AutoML)-based, data-driven, biomarker discovery pipeline approach, using genome-wide DNA methylation datasets laboratory...