A5006246278- Rheumatoid Arthritis Research and Therapies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Autoimmune and Inflammatory Disorders Research
- Asthma and respiratory diseases
University of Gothenburg
2022-2024
Abstract Background Activated fibroblast-like synoviocytes (FLS) are drivers of synovitis and structural joint damage in rheumatoid arthritis (RA). Despite the use disease-modifying drugs, only about 50% RA patients reach remission real-world settings. We used an unbiased approach to investigate effects standard-of-care methotrexate (MTX) a Janus kinase inhibitor, tofacitinib (TOFA), on gene expression RA-FLS, order identify untargeted disease mediators. Methods Primary RA-FLS were activated...
Abstract Background The role of the lung for initiation and progression rheumatoid arthritis (RA) is still unclear. Up to 10% RA patients develop interstitial disease which remains a clinical challenge. Understanding early mechanisms great importance. objective this study was determine whether there an association between peripheral neutrophil phenotypes presence pulmonary abnormalities (PA) on chest high-resolution computed tomography (HRCT) in untreated (ueRA). Methods Clinical data blood...
Abstract Background: The role of the lung for initiation and progression rheumatoid arthritis (RA) is still unclear. Up to 10% RA patients develop severe treatment resistant disease. Understanding early disease mechanisms great importance. objective this study was determine whether there an association between peripheral neutrophil phenotypes presence pulmonary abnormalities (PA) on chest high-resolution computed tomography (HRCT) in untreated (ueRA). Methods: Clinical data blood were...