A5040369884- CRISPR and Genetic Engineering
- DNA Repair Mechanisms
- Malaria Research and Control
- PARP inhibition in cancer therapy
- Early Modern Spanish Literature
- Retinal Development and Disorders
- Cultural and Mythological Studies
- Coronary Interventions and Diagnostics
- Mosquito-borne diseases and control
- Thyroid Disorders and Treatments
- Microbial Metabolic Engineering and Bioproduction
- Philosophy, Health, and Society
- Nutrition, Genetics, and Disease
- Historical Studies in Latin America
- Developmental and Educational Neuropsychology
- Thyroid Cancer Diagnosis and Treatment
- Educational Technology in Learning
- Veterinary Oncology Research
- Mechanical Circulatory Support Devices
- BRCA gene mutations in cancer
- Insect symbiosis and bacterial influences
- Libraries, Manuscripts, and Books
- Cardiac Structural Anomalies and Repair
- Cerebrovascular and Carotid Artery Diseases
- Microtubule and mitosis dynamics
University of Bern
2021-2024
Abstract Histone H2AX plays a key role in DNA damage signalling the surrounding regions of double-strand breaks (DSBs). In response to damage, becomes phosphorylated on serine residue 139 (known as γH2AX), resulting recruitment repair effectors 53BP1 and BRCA1. Here, by studying resistance poly(ADP-ribose) polymerase (PARP) inhibitors BRCA1/2-deficient mammary tumours, we identify function for γH2AX orchestrating drug-induced replication fork degradation. Mechanistically, γH2AX-driven...
Abstract Parasitic diseases, particularly malaria (caused by Plasmodium falciparum ) and theileriosis Theileria spp .), profoundly impact global health the socioeconomic well-being of lower-income countries. Despite recent advances, identifying host metabolic proteins essential for these auxotrophic pathogens remains challenging. Here, we generate a novel model human hepatocytes infected with P. integrate it genome-wide CRISPR knockout screen targeting -infected cells to pinpoint shared...
Thyrotropin receptor (TSHR), sodium iodide symporter (NIS), pendrin, and thyroid peroxidase (TPO) are essential for the uptake of iodine by follicular cells. The aim this study was to establish immunohistochemistry (IHC) protocols TSHR, NIS, TPO in canine tissues characterize their expression organoids derived from cell carcinoma (FTC) respective primary tumors. This constitutes a fundamental step as model FTC. Commercially available antibodies directed against human proteins were selected....
Desde el Cours du Collège de France (1975 /1976) Michel Foucault, titulado Il faut defender la societé (la 1ª edición en español, lo tituló: Genealogía del racismo: guerra razas al racismo Estado, sin justificación o base editorial e institucional alguna) se hace un análisis poder (fuerza y ley) vacío violencia estructural que existe hasta consolidación teoría doctrina jurídica—política soberanía los contractualistas, especialmente Thomas Hobbes. Se aportan tres ejemplos: dos muestras,...
The impact of Ambrogio Traversari’s (1386-1439) translation Diogenes Laertius’ De vitis et sen-tentiæ philosophorum (1433) on Nicholas Cusa’s venatione sapientiæ(1462) in relation to the skeptical tradition.
Taxanes are frequently used anticancer drugs known to kill tumor cells by inducing mitotic aberrations and segregation defects. A defining feature of specific cancers, notably triple-negative breast cancer (TNBC) particularly those deficient in BRCA1, is chromosomal instability (CIN). Here, we focused on understanding the mechanisms docetaxel-induced cytotoxicity, especially context BRCA1-deficient TNBC. Using functional genetic screens CIN+ cells, identified genes that mediate docetaxel...
Histone H2AX plays a key role in DNA damage signalling the surrounding regions of double-strand breaks (DSBs) 1,2 . In response to damage, becomes phosphorylated on serine residue 139 (known as γH2AX), resulting recruitment repair effectors 53BP1 and BRCA1 3–6 Here, by studying resistance poly(ADP-ribose) polymerase (PARP) inhibitors BRCA1/2-deficient mammary tumours 7,8 , we identify novel function for γH2AX orchestrating drug-induced replication fork degradation. Mechanistically,...
SUMMARY Apicomplexan parasite diseases, including malaria ( Plasmodium ) and theileriosis Theileria ), pose a significant threat to global health the socioeconomic well-being of low-income countries. Despite recent advances, common host metabolic proteins essential for these highly auxotrophic pathogens remain elusive. Here, we present comprehensive investigation integrating model P. falciparum parasites in hepatocytes genome-wide CRISPR screen targeting schizont-infected macrophages. We...

 Durante los días 12 y 13 de mayo se llevó a cabo el Primer Congreso Prevención Genómica organizado por la Asociación Argentina Oncología Clínica que contó con auspicios ONGs, 14 sociedades científicas (hechos inéditos en una actividad académica), organismos oficiales como Instituto Nacional del Cáncer, Ministerios Salud las Provincias Córdoba Neuquén, declarado interés sanitario Legislatura Porteña.