A5039879292- Cardiac Fibrosis and Remodeling
- Viral Infections and Immunology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- Peroxisome Proliferator-Activated Receptors
- Phagocytosis and Immune Regulation
- RNA Research and Splicing
- Immune Cell Function and Interaction
MRC London Institute of Medical Sciences
2023
Hammersmith Hospital
2023
Institute of Clinical Research
2023
Imperial College London
2023
The Royal Free Hospital
2008
Roland Hill (United Kingdom)
2008
University College London
2008
Cardiac fibrosis is a common pathological process in heart disease, representing therapeutic target. Transforming growth factor β (TGFβ) the canonical driver of cardiac and was recently shown to be dependent on interleukin 11 (IL11) for its profibrotic effects fibroblasts. In opposite direction, recombinant human IL11 has been reported as anti-fibrotic anti-inflammatory mouse heart. this study, we determined expression cardiomyocytes pathobiology function. We used Cre-loxP system generate...
Abstract Background: Cardiac fibrosis is a common pathological process in heart disease and represents therapeutic target. TGFβ the canonical driver of cardiac was recently shown to be dependent on IL11 for its profibrotic effects fibroblasts. In opposite direction, recombinant human has been reported as anti-fibrotic also anti- inflammatory mouse heart. Objectives: this study, we determined expression cardiomyocytes pathobiology function. Methods: We used Cre-loxP system generate...
Monocyte recruitment into the mesangium and foam cell formation are recognized features of glomerular injury. External signals encountered by infiltrating mononuclear cells may determine their behaviour thereby potentially influence disease outcome. Having previously demonstrated that monocytes activated exposure to matrix secreted mesangial cells, we set out whether activation led expression a macrophage phenotype.THP-1 were incubated for up 120 h (5 days) with 500 microg/ml solublized...
<h3>Introduction</h3> Fibrosis and inflammation are key pathophysiological factors in heart failure (HF) however no specific therapies exist which target these pathways. The interleukin-11 (IL11) cytokine was initially described as anti-inflammatory, cardioprotective important for platelet production. However, while recombinant IL11 is used to treat thrombocytopenia it causes serious but unexplained cardiac side-effects, including HF. Serum elevated HF patients murine models the effect of on...
Abstract Background Interleukin 11 (IL11) was initially thought important for platelet production, which led to recombinant IL11 being developed as a drug treat thrombocytopenia. later found be redundant haematopoiesis and its use in patients is associated with unexplained cardiac side effects. Here we identify previously unappreciated direct cardiomyocyte toxicities therapy. Methods We injected mouse lL11 (rmIL11) into mice studied molecular effects the heart using immunoblotting, qRT-PCR,...