A5067070761- Trauma and Emergency Care Studies
- Pelvic and Acetabular Injuries
- Emergency and Acute Care Studies
- Abdominal Trauma and Injuries
- Medical Practices and Rehabilitation
- Trauma Management and Diagnosis
- Medical and Health Sciences Research
- Spinal Fractures and Fixation Techniques
- Palliative Care and End-of-Life Issues
- Hip and Femur Fractures
- Cancer-related Molecular Pathways
- Restraint-Related Deaths
- Orthopedic Surgery and Rehabilitation
- Clinical practice guidelines implementation
- Traumatic Ocular and Foreign Body Injuries
- Shoulder Injury and Treatment
- Musculoskeletal Disorders and Rehabilitation
- Injury Epidemiology and Prevention
- Shoulder and Clavicle Injuries
- Lipid Membrane Structure and Behavior
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Bone Metabolism and Diseases
- Fungal and yeast genetics research
University Hospital of Zurich
2024
University of Zurich
2024
Schön Klinik Hamburg Eilbek
2021-2023
Charité - Universitätsmedizin Berlin
2003-2020
Asklepios Klinik St. Georg
2019-2020
Asklepios Fachklinikum Brandenburg
2017-2018
Bundesministerium für Umwelt, Naturschutz, nukleare Sicherheit und Verbraucherschutz
2018
Humboldt-Universität zu Berlin
2018
Freie Universität Berlin
2018
Leibniz University Hannover
2017
Ubiquitin ligases are generally assumed to play a major role in substrate recognition and thus provide specificity particular ubiquitin modification system. The multicopy maintenance protein (Mcm) 7 subunit of the replication licensing factor-M was identified as E3-ubiquitin ligase/E6-AP by its interaction with human papillomavirus-18E6. Mcm7 is ubiquitinated vivo both an E6-AP-dependent -independent manner. E6-AP functions these reactions independently viral oncogene E6. We show that...
Urocortin 3 (UCN3) is strongly expressed in specific nuclei of the rodent brain, at sites distinct from those expressing urocortin 1 and 2, other endogenous ligands corticotropin-releasing hormone receptor type 2 (CRH-R2). To determine physiological role UCN3, we generated UCN3-deficient mice, which UCN3 open reading frame was replaced by a <i>tau-lacZ</i> reporter gene. By means this gene, nucleus parabrachialis premammillary were identified as previously unknown expression. Additionally,...
Background Vagus nerve stimulation is increasingly applied to treat epilepsy, psychiatric conditions and potentially chronic heart failure. After implanting vagus electrodes the cervical nerve, side effects such as voice alterations dyspnea or missing therapeutic are observed at different frequencies. Cervical branching might partly be responsible for these effects. However, has not yet been described in context of stimulation. Materials Methods Branching was investigated macroscopically 35...
We show here using synchronized Swiss mouse 3T3 fibroblasts that p70 S6 kinase (p70S6k) and mitogen-activated protein kinases (p42mapk/p44mapk) are not only activated at the G0/G1 boundary, but also in cells progressing from M into G1. p70S6k activity increases 20-fold G1 released G0. Throughout G1, S, G2 it decreases constantly, so during phase low is measured. The reactivated 10-fold when a nocodazole-induced metaphase block enter of next cell cycle. p42mapk/p44mapk G0 transiently early...
Background: The surgical treatment for displaced humeral head fractures overlooks a broad variety of techniques and implant systems. A standard operative procedure has not yet been established. In this article, we report our experience with second-generation locking plate the fracture that is applied in standardized nine-step minimally invasive technique (MIS). Methods: prospective study from May 2008 until November 2009, cohort 79 patients 80 proximal humerus were operated MIS using...
Abstract We have cloned a new gene, SCP160 , from Saccharomyces cerevisiae the deduced amino acid sequence of which does not exhibit overall similarity to any known yeast protein. A weak resemblance between C‐terminal part Scp160 protein and regulatory subunits cAMP‐dependent kinases eukaryotes as well pstB Escherichia coli was observed. The gene resides on left arm chromosome X codes for polypeptide molecular weight around 160 kDa. By immunofluorescence microscopy appears be localized...
In unstable pelvic ring fractures free abdominal fluid on ultrasound (US) may be caused by retroperitoneal hematoma that passes into the cavity or an additional intraabdominal lesion. this study a clinical pathway for therapy of potentially combined lesions was analyzed.All patients treated in ED severe trauma underwent basic sonographical and radiologic diagnostics within 15 minutes. admission. Data were prospectively documented. According to treatment protocol with initial US received...
Approximately 30% of coronary angiograms are negative for significant artery disease and patients classified as having noncardiac chest pain (NCCP). So far, no systematic diagnostic approach to with NCCP investigating possible esophageal, psychiatric musculoskeletal abnormalities exists. Furthermore, coping strategies quality life poorly characterized in patients.A simple was applied 37 consecutive (21 female, age 61+/-12 years) angina-like normal angiograms. Twenty-one were found suffer...
A new class of fully synthetic shell cleavable multivalent polysulfates is prepared by introducing degradable linkers into a stable biocompatible dendritic polyglycerol scaffold and subsequent sulfation. The sulfated polymers show different degradation profiles, low anticoagulant high anti-inflammatory properties, are able to efficiently bind L-selectin inhibit the complement activation at very concentrations in vitro.
Regional differences in the care of severely injured patients remain problematic industrial countries.In 2006, German Society for Trauma Surgery initiated foundation regional networks between trauma centers a TraumaNetwork (TNW). The TNW consisted five major elements as follows: (a) whitebook on treatment patients; (b) evidence-based guidelines (S3); (c) local audits; (d) contracts interhospital cooperation among all participating hospitals; and (e) TraumaRegister documentation. hospitals...
Abstract Understanding the mechanism of interactions nanomaterials at biointerfaces is a crucial issue to develop new antimicrobial vectors. In this work, series water‐soluble fullerene‐polyglycerol sulfates (FPS) with different fullerene/polymer weight ratios and varying numbers polyglycerol sulfate branches are synthesized, characterized, their two distinct surfaces displaying proteins involved in target cell recognition investigated. The combination polyanionic solvent exposed variable...