A5070770782- Amino Acid Enzymes and Metabolism
- Polyamine Metabolism and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Organophosphorus compounds synthesis
- Chemical Synthesis and Analysis
- Nicotinic Acetylcholine Receptors Study
- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmaceutical and Antibiotic Environmental Impacts
- Biochemical and Molecular Research
- HIV/AIDS drug development and treatment
- Protein Hydrolysis and Bioactive Peptides
- Synthesis and Biological Evaluation
Engelhardt Institute of Molecular Biology
2020-2023
The fast spread of bacteria that are resistant to many classes antibiotics (multidrug resistant) is a global threat human and animal health with worrisome scenario ahead. Novel therapeutical strategies crucial importance combat this phenomenon. For purpose, we investigated the antimicrobial properties naturally occurring tripeptide Bialaphos dipeptide L-leucyl-L-phosphinoithricin, synthesis diastereomers separation which herein described. We demonstrate these compounds effective on clinical...
New antibiotics are unquestionably needed to fight the emergence and spread of multidrug-resistant bacteria. To date, targeting bacterial central metabolism have been poorly investigated. By determining minimal inhibitory concentration (MIC) desmethylphosphinothricin (Glu-γ-PH), an analogue glutamate with a phosphinic moiety replacing γ-carboxyl group, we previously showed its promising antibacterial activity on Escherichia coli. Herein, synthetized determined growth inhibition exerted E....
The biogenic polyamines, spermidine (Spd) and spermine (Spm), are present at millimolar concentrations in all eukaryotic cells, where they participate the regulation of vitally important cellular functions. Polyamine analogs derivatives a traditional instrument for investigation functions enzymes their metabolism, biosynthesis antizyme—a key downregulator polyamine homeostasis. Here, we describe convenient gram-scale syntheses set C-methylated Spd. biochemical properties these compounds...
Oligoarginine peptides, known mostly for their cell-penetrating properties, are also inhibitors of the nicotinic acetylcholine receptors (nAChRs). Since octa-arginine (R8) inhibits α9α10 nAChR and suppresses neuropathic pain, we checked if other polycationic compounds containing amino and/or guanidino groups could be effective tested activity disulfide-fixed “cyclo”R8, a series biogenic polyamines (putrescine, spermidine, spermine), C -methylated spermine analogs, agmatine its as well...
New antibiotics are unquestionably needed in the fight to emergence and spread of multidrug-resistant bacteria. So far, targeting bacterial central metabolism have been poorly investigated. By determining minimal inhibitory concentration (MIC) desmethylphosphinothricin (Glu-γ-PH), an analogue glutamate with a phosphinic moiety re-placing γ-carboxyl group, we previously showed its promising antibacterial activity on Escherichia coli. Herein synthetized determined growth inhibition exerted E....