A5055449146- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Bioenergy crop production and management
- MicroRNA in disease regulation
- Plant Genetic and Mutation Studies
- DNA Repair Mechanisms
- Plant Micronutrient Interactions and Effects
McGill University
2022-2024
University of Toronto
2016-2020
Canada Research Chairs
2016
Dietary calorie restriction is a broadly acting intervention that extends the lifespan of various organisms from yeast to mammals. On another front, magnesium (Mg2+) an essential biological metal critical fundamental cellular processes and commonly used as both dietary supplement treatment for some clinical conditions. If connections exist between Mg2+ unknown. Here, we show Mg2+, alone or in response restriction, allows eukaryotic cells combat genome-destabilizing lifespan-shortening...
Abstract Animal development is dictated by the selective and timely decay of mRNAs in developmental transitions, but impact mRNA decapping scaffold proteins unknown. This study unveils roles interactions DCAP-2 scaffolds EDC-3 EDC-4 embryonic C. elegans . facilitates removal specific mRNAs, including cgh-1, car-1, ifet-1 reducing their expression, preventing excessive accumulation condensates somatic cells. We further uncover a novel role for defining boundaries between P-bodies, germ...