A5010487157- Influenza Virus Research Studies
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Phagocytosis and Immune Regulation
- Tryptophan and brain disorders
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Galectins and Cancer Biology
- Helicobacter pylori-related gastroenterology studies
- Respiratory viral infections research
- Insect symbiosis and bacterial influences
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Hepatitis C virus research
- Inflammasome and immune disorders
Changchun University of Chinese Medicine
2023-2025
Third Affiliated Hospital of Sun Yat-sen University
2024-2025
Sun Yat-sen University
2024-2025
Shandong University
2023
T cell immunoglobulin and mucin-containing molecule 3 (Tim-3), expressed in dysfunctional exhausted cells, has been widely acknowledged as a promising immune checkpoint target for tumor immunotherapy. Here, using strategy combining virtual functional screening, we identified compound named ML-T7 that targets the FG-CC′ cleft of Tim-3, highly conserved binding site phosphatidylserine (PtdSer) carcinoembryonic antigen–related adhesion 1 (CEACAM1). enhanced survival antitumor activity primary...
CD155 is a crucial factor in the regulation of T cell function and contributes to immune escape. upregulation has been found several types cancer. However, mechanism by which regulates CD8+ colorectal cancer remains unclear. Here we investigated role function. We studied expression tissues through western blot, immunohistochemistry, TCGA database. verified effects on functions cells vitro experiments. demonstrated that affects migration thus promotes tumor growth mouse subcutaneous model....
To develop efficient diagnostic and treatment approaches, gaining an in-depth knowledge of the molecular mechanisms potential targets causing childhood asthma is utmost significance. Childhood datasets were obtained from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) between asthmatic child healthy people screened by Limma package. DEGs subjected to further analyses utilizing GO, KEGG GSEA analysis. The hub associated with discovered PPI drugs target accessed...
Immunotherapy for colorectal cancer (CRC) with microsatellite stability (MSS) and mismatch repair proficiency (pMMR) has shown limited success in clinical trials. The combination of immunomodulators immune checkpoint inhibitors (ICIs) is a potential strategy treating CRC. Histone deacetylase (HDAC) indoleamine 2,3-dioxygenase 1 (IDO1) expression CRC tissues adjacent normal was analyzed via database analysis, immunohistochemistry, western blotting. A nanodrug designated as NP-I/P subsequently...
Influenza viruses pose a serious threat to human health, infecting hundreds of millions people worldwide each year, resulting in significant increase global morbidity and mortality. activity has declined at the onset COVID-19 pandemic, but genetic diversity B/Victoria lineage increased significantly during this period. Therefore, prevention treatment influenza B Victoria strain virus should continue attract research attention. In study, we found that Atractyloside A (AA), one effective...
Fu-Zheng-Xuan-Fei formula (FF) is a prescription that has been clinically used through the basic theory of traditional Chinese medicine (TCM) for treating viral pneumonia. Although FF possesses prominent clinical therapeutic effect, seldom pharmacological studies have reported on its anti-influenza B virus (IBV) activity. Influenza an acute infectious respiratory disease caused by influenza virus, which high annual morbidity and mortality worldwide. With global decline in COVID-19 control,...
We studied the viromes of three dominant mosquito species in Wenzhou, a coastal city Zhejiang Province, using metavirome sequencing, with 18 viral families identified. Viral sequences were verified by RT-PCR. The JEV E gene was most closely related to 1988 Korean strain. DENV 1997 Australian CHIKV-E1-1 1983 Senegal strain and belonged West African genotype CHIKV. Remarkably, this is first time that CHIKV has been detected Province. Mutations protein A226V may increase infectivity Ae....