A5103071300- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Microbial infections and disease research
- Genomics and Phylogenetic Studies
Texas A&M University
2023-2024
More and more Pseudomonas aeruginosa isolates have become resistant to antibiotics like carbapenem. As a consequence, P. ranks in the top three of pathogens for which development novel is most crucial. The pathogen causes both acute chronic infections, especially patients who are vulnerable. Therefore, efforts urgently needed develop alternative therapies. One path explored this article use bacteriophages and, specifically, phage-derived proteins. In study, protein was studied that impacts...
Summary In microbial communities, viruses compete for host cells to infect, and thus evolved diverse ways inhibit their competitors. One mechanism is Superinfection exclusion (Sie), whereby a virus that has established an infection prevents secondary infection. We identified Pseudomonas prophage Sie protein alters pilus dynamics through the assembly chaperone, PilZ. This protein, known as Zip Pil Z i nteracting p rotein, does not abrogate activity, but fine tunes it, providing strong phage...
Type IV pili (T4P) are thin, flexible filaments exposed on the cell surface of gram-negative bacteria and involved in pathogenesis-related processes, including adsorption, biofilm formation, twitching motility. Bacteriophages often use these as receptors to infect host cells. Here, we describe identification a protein that inhibits T4P assembly Pseudomonas aeruginosa, discovered during screen for factors influencing phage infection. We show expression PA2560 (renamed PlzR) P. aeruginosa...