A5095040300- Immune cells in cancer
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Mental Health Research Topics
Medical University of South Carolina
2024-2025
Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive associated with mood and substance use disorders. These adaptations are supported part by experience-dependent activation of immediate-early response genes, such as
Abstract Neuronal activation induces immediate early response genes expression, essential for behavioral adaptation to emotional stimuli. Npas4 is rapidly induced by synaptic activity, regulating responses cocaine reward conditioning and chronic stress. A novel long non-coding RNA (LncRNA) transcribed from enhancer identified as stimuli-induced mRNA expression formation of reward-associated context in NAc stress-induced deficits sucrose preference mPFC. Notably, LncRNA forms DNA:RNA hybrid...