Microtubules and molecular motors are essential components of the cellular cytoskeleton, driving fundamental processes in vivo, including chromosome segregation cargo transport. When reconstituted vitro, these cytoskeletal proteins serve as energy-consuming building blocks to study self-organization active matter. Cytoskeletal gels display rich emergent dynamics, extensile flows, locally contractile asters, bulk contraction. However, it is unclear how protein–protein interaction kinetics set...

The spontaneous formation of contractile asters is ubiquitous in reconstituted active materials composed biopolymers and molecular motors. Asters are radially oriented or biopolymer bundles with a dense motor-rich core. microscopic origins their material properties stability unknown. Recent efforts highlighted how motor-filament filament-filament interactions control the microtubules kinesin However, impact motor-motor less understood, despite growing evidence that motors often spontaneously...

Abstract How active stresses generated by molecular motors set the large-scale mechanics of cell cytoskeleton remains poorly understood. Here, we combine experiments and theory to demonstrate how emergent properties a biomimetic crosslinked gel depend on its microscopic constituents. We show that an extensile nematic elastomer exhibits two distinct activity-driven instabilities, spontaneously bending in-plane or buckling out-of-plane depending composition. Molecular play dual antagonistic...

Active nematic liquid crystals have the remarkable ability to spontaneously deform and flow in absence of any external driving force. While living materials with orientational order, such as mitotic spindle, can self-assemble quiescent active phases, reconstituted systems often display chaotic, periodic, or circulating flows under confinement. Quiescent nematics are, therefore, quite rare, despite prediction from hydrodynamic theory that confinement between two parallel plates suppress...

Background: Menstrual hygiene refers to the safe and easy access menstrual products, infrastructure, information, supplies, necessary for menstruating women cope with their menstruation decorum console, along systemic factors linking health, empowerment gender equality among other things. The effects of unmet needs on women's health have been subject very little research. Women around globe widespread unmet-menstrual-health requirements, including inability safe, clean facilities cheap...

Nutrition knowledge is essential for the prevention of nutrition-related problems. Knowledge a familiarity, awareness, or understanding someone something, such as facts, information, descriptions, skills, which acquired through experience education by perceiving, discovering, learning. Objective: To determine relationship between maternal nutritional and children's growth under 5 years age in Lakhodair community, Lahore Pakistan. Methods: A quantitative correlational study design was used to...

Respiratory distress leads to neonatal morbidity and mortality. The premature rupture of membranes before labor at less than 37 weeks. Objectives: To determine the frequency respiratory in newborns delivered with preterm membranes. Methods: Cross-sectional study conducted Gynecology unit Ayub Teaching Hospital Abbottabad from 1-4-2018 1-9-2018. Sample size 244 was calculated using WHO software by non-probability consecutive sampling a convenience technique. Pregnant women singleton...

Ovarian cancer ranks as the seventh most frequently diagnosed malignancy among women worldwide. Endometrioid carcinoma, a type of proliferative endometrial tumor, accounts for approximately 15% epithelial ovarian cancers, making it third common subtype. Objective: To investigate relationship between Carcinoma and potential risk factors, including demographic, reproductive, lifestyle factors. Methods: A cross-sectional study was conducted at Hayatabad Medical Complex's Department Pathology...

Strong contractions that prevent the fetus from moving through birth canal, known as obstructed labour, were often due to a mismatch between size of fetal head and pelvis. Despite being preventable, this condition significantly contributes maternal neonatal morbidity mortality is leading cause hospitalization. Objective: To assess frequency types adverse outcomes associated with labour in Tertiary Care Hospital, Dera Ismail Khan. Methods: This cross-sectional study was conducted at...

Introduction: Polycystic ovary syndrome (PCOS) is the most common cause of chronic hyper androgenic anovulation and single infertility in young women. Anovulatory cycles are frequent adolescents. The signs adult hyperandrogenism less reliable adolescents than adults: hirsutism a developmental phase, acne vulgaris common. Objective: To determine frequency polycystic disease adolescent presented to outdoor. Study Design Setting: This cross sectional study was carried out Department Obstetrics...

Background: Anemia is the most common health problem during a woman life span. It has serious threats to pregnant women all over world. Its prevalence in Pakistan 75%. Thalassemia trait cause of anemia usually diagnosed pregnancy after workup anemia. Objective: To find out frequency beta thalassemia anemic women. Study Design: Cross-sectional study. Settings: Gynecology Unit, Hayatabad Medical Complex, Peshawar Pakistan. Duration: 6 months from 9th September 2020 8th march 2021. Methods: A...

Endothelium is one of the largest organ by area and consist at least trillion endothelial cells having more than 100 gram weight covering 3000 square meters in an adult human body. interacts with most body systems implicated end diseases particularly cardiovascular. The endothelium maintains vascular tone precisely regulating vasodilatation vasoconstriction while effectively providing adequate supply blood to target organs. Factors that affect subsequently cardiovascular system include...

Abstract Microtubules and molecular motors are essential components of the cellular cytoskeleton, driving fundamental processes in vivo, including chromosome segregation cargo transport. When reconstituted vitro , these cytoskeletal proteins serve as energy-consuming building blocks to study self-organization active matter. Cytoskeletal gels display rich emergent dynamics, extensile flows, locally contractile asters, bulk contraction. However, how protein-protein interaction kinetics set...

Introduction: Using acetic acid to inspect the vaginal canal is a simple screening procedure done with naked eye. During speculum examination, cervical transformation zone painted 3% 5% or vinegar. It simple, cost-effective tool that can be used in poor developing countries high rates of invasive cancer mortality because coagulates nuclear proteins, resulting white discoloration CIN and early cancer. Objective: This study aims measure effectiveness economical test, visual inspection (VIA),...

Objective: To determine the frequency of factors leading to oligohydramnios in patients presenting women and children hospital, Dera Ismail Khan. Materials methods: This cross sectional study was conducted obstetrics gynecology department, Women teaching hospital khan from 1 August, 2020 31 January, 2021, comprising 185 patients. Sampling technique used convenient non-probability sampling. Factors (Primigravida, history abortion, gestational age > 40 weeks, UTI high blood pressure) were...

Background: Macrosomia or big baby is defined as a newborn with birth weight of more than 4kg. Amniotic fluid index (AFI) which estimated by adding length deepest vertical pool in four corners liquor uterus an indicator fetal well-being. This parameter when combined ultrasonographic can predict macrosomia accurately. Objective: To evaluate diagnostic accuracy integrated examination amniotic and (EFW) for prediction macrosomia. Study Design: Cross sectional study. Settings: Department...