A5051010838- Oxidative Organic Chemistry Reactions
- Catalytic C–H Functionalization Methods
- Synthesis and Biological Evaluation
- Sulfur-Based Synthesis Techniques
- Synthesis and Catalytic Reactions
- Synthesis and biological activity
- Synthesis of heterocyclic compounds
Incheon National University
2022-2024
Abstract A one‐pot synthesis of 2‐imino‐1,3,4‐thiadiazolines was successfully achieved under mild conditions. The developed involves Fe(Pc)‐catalyzed aerobic oxidation acylhydrazides followed by P(NMe 2 ) 3 ‐mediated annulation the in situ generated N ‐acyldiazene with isothiocyanates. present showed broad substrate scope good functional group tolerance, and effective on gram scale.
Azo compounds such as diethyl azodicarboxylate have been used in oxidative coupling reactions to generate iminium ions from tertiary amines. However, the requirement of stoichiometric amounts azo limits their large-scale applications. Herein, we present an aerobic α-cyanation amines using catalytic compound or hydrazine. The developed protocol provides a practical and ecofriendly route for α-cyanated amines, molecular oxygen terminal oxidant.
The framework of 1,3,4-oxadiazine is crucial for numerous bioactive molecules, but only a limited number synthetic methods have been reported its production. In 2015, Wang's group developed 4-(dimethylamino)pyridine (DMAP)-catalyzed [2 + 4] cycloaddition allenoates with N-acyldiazenes, which provided an atom-efficient route 1,3,4-oxadiazines. However, the practicality this method was by instability N-acyldiazenes as starting materials. Building upon our ongoing research about aerobic...