A5016386416- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Semiconductor Lasers and Optical Devices
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Advanced MRI Techniques and Applications
- Radiology practices and education
- Bipolar Disorder and Treatment
- Metabolism, Diabetes, and Cancer
- Intracranial Aneurysms: Treatment and Complications
- Growth Hormone and Insulin-like Growth Factors
- Fetal and Pediatric Neurological Disorders
- Genetic Syndromes and Imprinting
- Cerebrovascular and Carotid Artery Diseases
- 14-3-3 protein interactions
- Advanced Proteomics Techniques and Applications
- Advanced Optical Network Technologies
- Electrolyte and hormonal disorders
- Characterization and Applications of Magnetic Nanoparticles
- RNA and protein synthesis mechanisms
- Machine Learning in Bioinformatics
- Cancer, Lipids, and Metabolism
- Adrenal and Paraganglionic Tumors
- Head and Neck Anomalies
University of South Australia
2015-2022
Centre for Cancer Biology
2013-2022
South Australia Pathology
2013-2022
The University of Adelaide
2009-2022
University Hospital Galway
2013-2022
Ollscoil na Gaillimhe – University of Galway
2012-2020
Beaumont Hospital
2017
University of Rochester
2014
Wellcome Centre for Human Neuroimaging
2012
King's College London
2012
Insulin-like growth factor binding proteins (IGFBP-1 to -6) bind insulin-like factors-I and -II (IGF-I IGF-II) with high affinity. These maintain IGFs in the circulation direct them target tissues, where they promote cell growth, proliferation, differentiation, survival via type 1 IGF receptor. IGFBPs also interact many other molecules, which not only influence their modulation of action but mediate IGF-independent activities that regulate processes such as migration apoptosis by modulating...
Although repeatedly associated with white matter microstructural alterations, bipolar disorder (BD) has been relatively unexplored using complex network analysis. This method combines structural and diffusion magnetic resonance imaging (MRI) to model the brain as a evaluate its topological properties. A group of highly interconnected high-density structures, termed 'rich-club', represents an important for integration functioning. study aimed assess rich-club connectivity properties in BD...
Objectives A broad range of subtle and markedly heterogenous neuroanatomical abnormalities grey matter white have been reported in bipolar disorder. Euthymic disorder patients represent a clinically homogenous group which to identify trait‐based biomarkers In this study, we sought clarify the nature extent differences large, homogeneous euthymic patients. Methods Structural magnetic resonance imaging ( sMRI ) was obtained for 60 with prospectively confirmed I individually age‐ gender‐matched...
Abstract Sequencing and expression analyses implicate 14-3-3ζ as a genetic risk factor for neurodevelopmental disorders such schizophrenia autism. In support of this notion, we recently found that −/− mice in the Sv/129 background display schizophrenia-like defects. As epistatic interactions play significant role disease pathogenesis generated new congenic strain BALB/c to determine impact on phenotype. addition replicating defects aberrant mossy fibre connectivity impaired spatial memory,...
Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- postsynaptic neurons. Regulation dopaminergic signalling is primarily achieved through reuptake extracellular DA by the transporter (DAT) presynaptic Aberrant regulation signalling, in particular hyperactivation, has been proposed as key insult presentation schizophrenia related neuropsychiatric disorders. We recently...
The Circle of Willis (CoW) is a complex pentagonal network comprised fourteen cerebral vessels located at the base brain. collateral flow feature within circle allows ability to maintain perfusion Unfortunately, this can create undesirable impact locations due anatomical variations CoW. interaction between hemodynamic forces and arterial wall are believed be involved in formation aneurysms, especially irregular geometries such as tortuous segments, bends, bifurcations. highest propensity...
Enterococcus faecalis is a significant nosocomial pathogen, which able to survive in diverse environments and resist killing with antimicrobial therapies. The expression of cell membrane proteins play an important role how bacteria respond environmental stress. As such, the capacity identify study protein critical our understanding specific influence bacterial survival. Here, we describe combined approach E. ATCC V583 using membranes fractionated by either 1D SDS/PAGE or shaving, coupled...
ABSTRACT Two anti- Aspergillus murine monoclonal antibodies (MAbs), designated 164G and 611F, have been produced; both specifically recognize cytoplasmic antigens of A. fumigatus , flavus niger by enzyme-linked immunosorbent assay. The MAbs can identify spp. in frozen sections immunofluorescence paraffin-embedded clinical specimens immunoperoxidase staining.
Abstract The ubiquitin ligase NEDD4 promotes neural crest cell (NCC) survival and stem-cell like properties to regulate craniofacial peripheral nervous system development. However, how ubiquitination control NCC development remains unknown. Here we combine quantitative analysis of the proteome, transcriptome ubiquitinome identify key developmental signalling pathways that are regulated by NEDD4. We report 276 targets in NCCs show loss leads a pronounced global reduction specific lysine...
Although acetylation is regarded as a common protein modification, detailed proteome-wide profile of this post-translational modification may reveal important biological insight regarding differential individual proteins. Here we optimized novel peptide IEF fractionation method for use prior to LC-MS/MS analysis obtain more in depth coverage N-terminally acetylated proteins from complex samples. Application the serous ovarian cancer cell line OVCAR-5 identified 344 proteins, 12 which are...
Abstract Enterococcus faecalis is able to adapt alkaline conditions and commonly recovered from teeth in which endodontic treatment has failed. The role that E. membrane proteins play survival strategies extreme unclear. We grew V583 a chemostat at pH 8 11 one-tenth the organism’s relative maximum growth rate. Following shaving, isotope-coding protein labels were added peptide level samples then combined. proportion of identified using LC-ESI mass spectrometry MaxQuant analysis. Ratios log2...