A5027032958- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Animal Genetics and Reproduction
- Developmental Biology and Gene Regulation
- CRISPR and Genetic Engineering
- Marine animal studies overview
- Single-cell and spatial transcriptomics
- Planarian Biology and Electrostimulation
- Marine and coastal plant biology
- Protist diversity and phylogeny
- Cephalopods and Marine Biology
- Animal Behavior and Reproduction
Duke University
2023-2024
National Institute of Diabetes and Digestive and Kidney Diseases
2024
National Institutes of Health
2024
Stanford University
2024
The developmental gene regulatory networks (dGRNs) of two sea urchin species, Lytechinus variegatus (Lv) and Strongylocentrotus purpuratus (Sp), have remained remarkably similar despite about 50 million years since a common ancestor. Hundreds parallel experimental perturbations transcription factors with outcomes support this conclusion. A recent scRNA-seq analysis suggested that the earliest expression several genes within dGRNs differs between Lv Sp. Here, we present careful reanalysis in...
ABSTRACT Biphasic lifecycles are widespread among animals, but little is known about how the developmental transition between larvae and adults regulated. Sea urchins a unique system for studying this phenomenon because of stark differences their bilateral larval pentaradial adult body plans. Here, we use single-cell RNA sequencing to analyze development Heliocidaris erythrogramma (He), sea urchin species with an accelerated, non-feeding mode development. The time course extends from...
Abstract Biphasic lifecycles are widespread among animals, but little is known about how the developmental transition between larvae and adults regulated. Sea urchins a unique system for studying this phenomenon because of stark differences their bilateral larval pentaradial adult body plans. Here, we use single cell RNA-sequencing to analyze development Heliocidaris erythrogramma ( He ), sea urchin species with an accelerated, non-feeding mode development. The sequencing time course extends...
The somatic sex determination gene
The somatic sex determination gene transformer ( tra ) is required for the highly sexually dimorphic development of most cells, including those gonads. In addition, germline even though it not within germ cells. Germ cell autonomous expression also necessary their determination. To understand interplay between these signals, we compared phenotype and larval wild-type gonads sex-transformed XX ovaries transformed into testes were dramatically smaller than wild-type, with significant...
The somatic sex determination gene transformer ( tra ) is required for the highly sexually dimorphic development of most cells, including those gonads. In addition, germline even though it not within germ cells. Germ cell autonomous expression also necessary their determination. To understand interplay between these signals, we compared phenotype and larval wild-type gonads sex-transformed XX ovaries transformed into testes were dramatically smaller than wild-type, with significant...