A5102940282- Prenatal Screening and Diagnostics
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Genomic variations and chromosomal abnormalities
- Genetic Syndromes and Imprinting
- Renal and related cancers
- Reproductive Health and Technologies
- Sperm and Testicular Function
- Epigenetics and DNA Methylation
- Chromosomal and Genetic Variations
- Gestational Trophoblastic Disease Studies
- Tumors and Oncological Cases
- Pluripotent Stem Cells Research
- Fetal and Pediatric Neurological Disorders
- Congenital Anomalies and Fetal Surgery
- Genomics and Rare Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Genomics and Diagnostics
- Birth, Development, and Health
- Genetics, Aging, and Longevity in Model Organisms
- Pregnancy and preeclampsia studies
- BRCA gene mutations in cancer
- Tissue Engineering and Regenerative Medicine
- Parvovirus B19 Infection Studies
- Genetic factors in colorectal cancer
Colorado Center for Reproductive Medicine
2014-2023
Reproductive Science Center
2020
Ovation Fertility
2020
Texas Fertility Center
2020
Oxford Fertility
2020
Fertility Centers of Illinois
2009-2020
University of California, San Diego
2016
National Foundation for Fertility Research
2010-2014
Reproductive Medicine Associates of New Jersey
2008-2012
Johnson University
2009-2010
The high frequency of chromosomal abnormalities observed in human gametes and embryos is unlike that seen other mammalian species great clinical significance, leading to rates pregnancy loss, live-born children with aneuploid syndromes. Although much known concerning the aneuploidy oocytes, cleavage stage fetuses during pregnancy, status blastocysts has been relatively little investigated. A total 158 good quality were examined using micromanipulation, whole genome amplification comparative...
STUDY QUESTIONWhen a chromosome aneuploidy is detected in the first polar body and reciprocal loss or gain of same second body, resulting embryo usually aneuploid for that chromosome?
Fluorescent in situ hybridization (FISH) studies of human preimplantation embryos have demonstrated a high proportion chromosomal mosaicism. To investigate the different timings and nature mosaicism, we developed single cell multiplex fluorescent (FL)-PCR to distinguish meiotic mitotic division errors. Chromosome 21 was investigated as model chromosome trisomy (Down's syndrome) represents most common aneuploidy that reaches live birth. Sister blastomeres from total 25 aneuploid were...
To demonstrate that a euploid embryo derived from an oocyte with reciprocal aneuploid polar bodies is capable of producing chromosomally normal child.A case report maternal MI error compensation where single nucleotide polymorphism (SNP) microarray based comprehensive chromosome screening (CCS) was performed on the 1st and 2nd body, resulting embryo, newborn DNA.CCS after transfer identified resulted bodies. The first body found to be missing chromatid 21 second possessed extra 21....
Objectives To develop a reliable method to isolate fetal cells for genetic diagnosis. Design Aspiration of cervical mucus from pregnant women in the first trimester. Setting Pregnant were recruited before an elective termination pregnancy. Population Sixty (7–10 weeks gestation). Methods Fetal isolated aspirated using combination enzymatic digestion, fluorescent immunohistochemistry, micromanipulation and single‐cell DNA allelic profiling. Main outcome measures The isolation identification...
To demonstrate that translocation carrier patients can be identified by analysis of chromosomes in preimplantation human embryos.A report 3 cases which multiple embryos were found to possess consistent segmental imbalances CCS. The parents then had a conventional karyotype performed.In each case, parental karyotyping revealed the presence an otherwise unknown balanced translocation. Original blastocyst CCS results reinterpreted consider unbalanced derivative and modify diagnosis eligible for...
What is the reproductive potential of embryos that achieve blastulation on day 7 followed by preimplantation genetic testing for aneuploidies (PGT-A) infertility patients with slow embryo development?This was a retrospective cohort study in private IVF clinic consecutive female (n = 2966) aged 24-48 (36.3 ± 3.8) years who underwent frozen transfer (FET) single euploid blastocyst.The women FET an achieved 5 1880), 6 986) or 100). Day resulted lower implantation and live birth rates compared...