A5055538391- Respiratory viral infections research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Insect and Pesticide Research
- Malaria Research and Control
- Influenza Virus Research Studies
- Complement system in diseases
- Entomopathogenic Microorganisms in Pest Control
- Retinoids in leukemia and cellular processes
- Insect Pest Control Strategies
- Redox biology and oxidative stress
- SARS-CoV-2 detection and testing
- Heat shock proteins research
- Cancer-related Molecular Pathways
- ATP Synthase and ATPases Research
- Immune Response and Inflammation
- Neuropeptides and Animal Physiology
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Nitric Oxide and Endothelin Effects
- Fibroblast Growth Factor Research
- Vitamin C and Antioxidants Research
- Travel-related health issues
- Erythrocyte Function and Pathophysiology
- Cytokine Signaling Pathways and Interactions
A*STAR Graduate Academy
2023-2024
Agency for Science, Technology and Research
2020-2022
Institute of Molecular and Cell Biology
2022
Singapore Immunology Network
2020
The University of Melbourne
2011-2015
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Please cite this paper as: Wong et al. (2011) Oseltamivir treatment of mice before or after mild influenza infection reduced cellular and cytokine inflammation in the lung. Influenza Other Respiratory Viruses 5(5), 343–350. Background Lung is a critical determinant outcomes but seldom evaluated animal studies oseltamivir (OS), which have focused on viral titre survival. Objectives To study effects pre‐ post‐infection dosing with OS replication mouse model non‐lethal infection. Methods BALB/c...
Inflammation is an important component of cancer diathesis and treatment-refractory inflammation a feature many chronic degenerative lung diseases. HSP90 90kDa protein which functions as ATP-dependent molecular chaperone that regulates the signalling conformation expression multiple client proteins especially oncogenic mediators. inhibitors are in clinical development therapies but myeleosuppressive neutropenic effect first generation geldanamycin-class has confounded studies on effects...
In malaria, rosetting is described as a phenomenon where an infected erythrocyte (IRBC) attached to uninfected erythrocytes (URBC). some studies, has been associated with malaria pathogenesis. Here, we have identified new type of rosetting. Using step-by-step approach, IGFBP7, protein secreted by monocytes in response parasite stimulation, rosette-stimulator for Plasmodium falciparum- and P. vivax-IRBC. IGFBP7-mediated rosette-stimulation was rapid yet reversible. Unlike I that involves...
Background Photorhabdus asymbiotica is a species of the insect pathogenic genus that has been isolated as an etiological agent in human infections. Since then, multiple isolates have identified worldwide; however, actual clinical infections so far only North America, Australia, and Nepal. Previous research on had shown strains differed their behaviour when infecting cultured cells. Methods In this study, we investigate differences between activities P. from different geographic locations....
AOD01 is a novel, fully human immunoglobulin (Ig) G1 neutralizing monoclonal antibody that was developed as therapeutic against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). This first-in-human study assessed safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of in healthy volunteers. Intravenous doses were evaluated escalating cohorts [four single-dose (2, 5, 10, 20 mg/kg) one two-dose cohort (two mg/kg, 24 h apart)]. Twenty-three subjects randomized to...
<b>Introduction:</b> Respiratory syncytial virus (RSV) and rhinovirus (RV) infection associates with asthma/COPD exacerbation, which responds inadequately to glucocorticoids (GC). Viral induces transforming growth factor-β (TGF-β). TGF-β is a mediator of GC insensitivity in epithelial cell types (Salem, S. et al. Br J Pharmacol2012;166:2036-2048; Keenan, C.R. Respir Res 2014; 15:55) <b>Aim:</b> To explore the contribution RSV-induced insensitivity. <b>Methods:</b> Bronchial line BEAS-2B...
Abstract Photorhabdus asymbiotica is a species of the insect pathogenic genus that has been isolated as an etiological agent in human infections. Since then, multiple isolates have identified worldwide, however actual clinical infections so far only North America, Australia and Nepal. Previous research on had shown strains differed their behaviour when infecting cultured cells, based geographical site isolation. In this study we investigate differences between activities P. from different...