Li-Mei Chen

ORCID: 0009-0007-3014-539X
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About
Contact & Profiles
Research Areas
  • Language Development and Disorders
  • Phonetics and Phonology Research
  • Intergenerational Family Dynamics and Caregiving
  • Geriatric Care and Nursing Homes
  • Migration, Aging, and Tourism Studies
  • Influenza Virus Research Studies
  • Cerebral Palsy and Movement Disorders
  • Assistive Technology in Communication and Mobility
  • Respiratory viral infections research
  • Neurobiology of Language and Bilingualism
  • Infant Health and Development
  • Reading and Literacy Development
  • Speech Recognition and Synthesis
  • Healthcare Policy and Management
  • Electron and X-Ray Spectroscopy Techniques
  • Salmonella and Campylobacter epidemiology
  • Voice and Speech Disorders
  • earthquake and tectonic studies
  • Geological and Geochemical Analysis
  • Primary Care and Health Outcomes
  • Geochemistry and Geologic Mapping
  • Viral gastroenteritis research and epidemiology
  • Nonprofit Sector and Volunteering
  • Health disparities and outcomes
  • Subtitles and Audiovisual Media

George Mason University
2024

National Cheng Kung University
2005-2020

Taiwan Space Agency
2018

Centers for Disease Control and Prevention
2011-2015

Chinese Academy of Sciences
2013-2014

Kwansei Gakuin University
2008-2014

Beihua University
2014

Institute of Geochemistry
2013-2014

Shandong University
2011

Fu Jen Catholic University
1997-2009

Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature. The recent discovery of new H17N10 subtype Central American fruit bats suggests that other New World species may similarly carry divergent viruses. Using consensus degenerate RT-PCR, we identified novel virus, designated as H18N11, flat-faced bat (Artibeus planirostris) from Peru. Serologic studies with the recombinant H18 protein indicated several Peruvian were infected by this virus. Phylogenetic...

10.1371/journal.ppat.1003657 article EN cc-by PLoS Pathogens 2013-10-10

We have shown by a variety of microscopical and biochemical techniques that Salmonella spp. are cytotoxic for cultured J774A.1 bone marrow‐derived murine macrophages. The cytotoxicity is initially manifested inhibition membrane ruffling macropinocytosis in infected macrophages, followed cell death. Macrophages killed exhibited features apoptosis such as condensation fragmentation chromatin, blebbing, the presence cytoplasmic nucleosomes apoptotic bodies. Cytotoxicity does not require...

10.1046/j.1365-2958.1996.471410.x article EN Molecular Microbiology 1996-09-01

Highly pathogenic H5N1 avian influenza viruses have caused major disease outbreaks in domestic and free-living birds with transmission to humans resulting 59% mortality amongst 564 cases. The mutation of the amino acid at position 627 viral polymerase basic-2 protein (PB2) from glutamic (E) isolates lysine (K) human is frequently found, but it not known if this change affects fitness pathogenicity virus birds. We show here that horizontal A/Vietnam/1203/2004 (VN/1203) chickens ducks was...

10.1371/journal.pone.0030960 article EN cc-by PLoS ONE 2012-02-21

ABSTRACT The NS1 protein of human influenza A viruses binds the 30-kDa subunit cleavage and polyadenylation specificity factor (CPSF30), a required for 3′ end processing cellular pre-mRNAs, thereby inhibiting production beta interferon (IFN-β) mRNA. proteins pathogenic 1997 H5N1 contain CPSF30-binding site but lack consensus amino acids at positions 103 106, F M, respectively, that are stabilization CPSF30 binding, resulting in nonoptimal binding infected cells. Here we have demonstrated...

10.1128/jvi.00417-11 article EN Journal of Virology 2011-05-19

The Jinchuan Ni-Cu-(PGE) deposit is one of the world’s largest magmatic sulfide deposits. Recent studies have suggested that intrusion originally comprised two individual intrusions, Eastern and Western intrusions. consists an Upper a Lower unit. unit largely free sulfides with weakly disseminated only at base unit; these are characterized by moderate Cu/Pd ratios 5,500 to 14,900 relatively high PGE tenors (PGE in 100% sulfides) range 510 1,000 ppb Irsul, 420 1,200 Rusul, 2,900 8,000 Pdsul....

10.2113/econgeo.108.8.1793 article EN Economic Geology 2013-11-04

Research Article| September 01, 2014 Geochemistry Insights on the Genesis of Subduction-Related Heishan Magmatic Ni-Cu-(PGE) Deposit, Gansu, Northwestern China, at Southern Margin Central Asian Orogenic Belt* Wei Xie; Xie 1State Key Laboratory Ore Deposit Geochemistry, Institute Chinese Academy Sciences, 46th Guanshui Road, Guiyang, 550002, P. R. China Search for other works by this author on: GSW Google Scholar Xie-Yan Song; Song † †Corresponding author: e-mail, songxieyan@vip.gyig.ac.cn...

10.2113/econgeo.109.6.1563 article EN Economic Geology 2014-07-09

The increasing numbers of Asian and other immigrants in the United States have resulted greater demands for research methodology sensitive to cross-cultural issues. A regional probability sample (n = 407) elderly different nationalities (Chinese, Korean, Indian, Filipino, Vietnamese, or Japanese) residing New York City was used examine reliability Geriatric Depression Scale (GDS). Using 30-item GDS, about 40% this representative considered be depressed, indicating higher depression rates...

10.1017/s1041610203009517 article EN cc-by-nc-nd International Psychogeriatrics 2003-09-01

Purpose:An increasingly important task for all disciplines involved in aging research is to identify and prioritize areas investigation. This article reports the results of a national Delphi study on setting priorities gerontological social work. Design Methods:Delphi methodology, structured process eliciting correlating informed opinions from panel experts specific topic, was used. A expert 46 workers completed three successive Web-based questionnaires with controlled feedback delimit set...

10.1093/geront/43.6.828 article EN The Gerontologist 2003-12-01

The Accreditation Council for Graduate Medical Education (ACGME) Work-Hours Duty Policy became effective on July 1, 2003, mandating the reduction of resident duty work hours. Baylor College Medicine Multi-Institutional Integrated Plastic Surgery Program instituted a work-hours policy 2002 (1 year ahead national mandate). Outcomes data are needed to facilitate continuous improvements in plastic surgical residency training while maintaining high-quality patient care. To assess effect this...

10.1097/01.prs.0000142768.07468.64 article EN Plastic & Reconstructive Surgery 2004-12-01

Quail are thought to serve as intermediate hosts of influenza A viruses between aquatic birds and terrestrial birds, such chickens, due their high susceptibility aquatic-bird viruses, which then adapt replicate efficiently in new hosts. However, does replication quail similarly result efficient humans? Using sialic acid-galactose linkage-specific lectins, we found both avian (sialic acid-α2-3-galactose [Siaα2-3Gal] linkages on sialyloligosaccharides)--and human (Siaα2-6Gal)-type receptors...

10.1128/jvi.06100-11 article EN Journal of Virology 2011-11-17

Genetic structure and demographic history of shrimp Feneropenaeus chinensis were examined using sequence data from portions the mitochondrial cytochrome c oxidase I (COI) gene. Samples 91 individuals collected 5 localities over most species' range in Yellow Sea Bohai Sea. Variability was detected at a total 20 nucleotide sites, defining haplotypes COI this species. The level variation low, with H = 0.4816 +/- 0.0639 pi 0.0846 0.0711% respectively. Analysis molecular variance conventional...

10.5897/ajb2009.000-9190 article EN 2009-04-06

Underlining ecological theories of aging, we assessed the impact relocation, residential type, and individual lifestyle factors on structure health status overtime.From data Longitudinal Study Aging II, included older adults aged 70 (N = 5,294). To analyze longitudinal trajectories outcomes, Latent Growth Curve Modeling (LGCM) was employed.LGCMs supported that adults' relocation health-related lifestyles were important in preserving better outcomes. Multiple structural equations corroborated...

10.1177/0898264308328960 article EN Journal of Aging and Health 2008-12-30

Early prosodic development (f0 variation) was systematically measured in Mandarin-learning infants at the transition from babbling to producing first words. Spontaneous vocalizations of twenty-four aged 0 ; 7 1 6 were recorded 45-minute sessions. The speech production caregivers also audio-recorded during caregiver-infant natural daily interactions home. All recordings transcribed using broad patterns. Analysis revealed four major findings: (1) falling f0 contours more prominently produced...

10.1017/s0305000908008878 article EN Journal of Child Language 2008-08-27

Most studies on CV co-occurrence patterns in early phonetic development have been based Indo-European languages. Data from infants learning Mandarin, which has a substantially different phonological system languages, can confirm or refute the findings of previous studies, thus shedding further light theoretical bases association. Spontaneous vocalizations were recorded 45-minute sessions for each 24 Mandarin-learning aged 0;7 to 1;6. In addition, speech production caregivers was...

10.1017/s0305000905006896 article EN Journal of Child Language 2005-08-01

The early development of vocalic and consonantal production in Mandarin-learning infants was studied at the transition from babbling to producing first words. Spontaneous vocalizations were recorded for 24 grouped by age: G1 (0 ; 7 1 0) G2 (1 6). Additionally, infant-directed speech caregivers during natural infant-adult interactions infer language-specific effects. Data phonetically transcribed according broad categories vowels consonants. Vocalic development, comparison with reports...

10.1017/s0305000909009581 article EN Journal of Child Language 2009-06-03

This article describes a Delphi study to identify research priorities of gerontological social work practitioners and compare these with those academic researchers. A national expert panel 52 completed questionnaires delimit set high-priority topics. Findings were compared similar conducted The researcher the practitioner endorsed need for intervention research. Practitioners also identified several unique priorities, including income security long-term care policies, decision making,...

10.1093/swr/29.4.231 article EN Social Work Research 2005-12-01

Factors influencing caregivers' decisions to place their older family members in nursing homes were explored. Data based on interviews with primary caregivers, and patient records of a Geriatric Intermediate Care Facility during the eight-year data collection period. Findings show that over half caregivers (55%) decided member home due incapability providing care rather than adult's declining physical or cognitive functioning. Although it is reported Japanese, whose culture embedded filial...

10.2224/sbp.2009.37.3.393 article EN Social Behavior and Personality An International Journal 2009-04-01

10.1007/s12126-012-9168-x article EN Ageing International 2012-09-26
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