A5006329022- Microbial infections and disease research
- Childhood Cancer Survivors' Quality of Life
- Congenital Anomalies and Fetal Surgery
- Neonatal Respiratory Health Research
- Veterinary Oncology Research
- Veterinary Orthopedics and Neurology
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- NF-κB Signaling Pathways
- Reproductive Physiology in Livestock
- Immunotoxicology and immune responses
- Reproductive System and Pregnancy
- Voice and Speech Disorders
- Transgenic Plants and Applications
- Heterotopic Ossification and Related Conditions
- Olfactory and Sensory Function Studies
- Radiation Therapy and Dosimetry
- Anorectal Disease Treatments and Outcomes
- Hypothalamic control of reproductive hormones
- Dupuytren's Contracture and Treatments
- History of Medical Practice
- Virus-based gene therapy research
- Renal and related cancers
- Clusterin in disease pathology
- Advanced Synthetic Organic Chemistry
Merck & Co., Inc., Rahway, NJ, USA (United States)
2013-2023
United States Military Academy
2007-2023
La Roche College
1999
Colorado State University
1980-1988
Food Safety and Inspection Service
1981
Sherman Oaks Hospital
1981
The Scientific and Regulatory Policy Committee of the Society Toxicologic Pathology (STP) appointed a working group to address risk assessment for increases in alveolar macrophages following inhalation pharmaceutical materials. This position paper provides recommendations study–specific terminology interpretation based on literature information from marketed inhaled drugs. Based weight-of-the-evidence approach, with appropriate consideration physical pharmacological characteristics compound,...
Beginning in summer 1977 and continuing through four consecutive seasons, we examined lame limb joints from 106 partially fattened cattle 28,235 pairs of occipital condyles fully for osteochondrosis. Of the cattle, nine (8.5%) had characteristic lesions, usually their stifle joints, atlanto-occipital 1063 (3.8%) lesions on condyles. Slices affected articular cartilage subjacent bone were studied radiographically histologically. Radiographs showed subchondral defects epiphyseal “cyst-like”...
Recombinant rat growth hormone (rrGH) and recombinant mouse (rmGH) were developed to evaluate the potential carcinogenicity of each biologically active (GH) as assessed in respective species. Biological activities rrGH rmGH demonstrated by showing an increase body weight gain serum levels insulin-like factor-1 (IGF-1) hypophysectomized rats receiving daily sc injections for 6 days. With exception pharmacologically mediated gain, had no adverse effects 5-week oral toxicity studies production...
In a random sample of 30,444 larynges from slaughtered beef cattle, 441 (1.4%) had chronic diphtheria and 1,345 (4.4%) papillomatosis. Both types lesions were centered in mucous membranes over the vocal processes medial angles arytenoid cartilages. Since they are found same anatomical locations as laryngeal contact ulcers, we hypothesize that ulcers primary papillomatosis secondary.
Of 30,444 larynges from fattened cattle at three companies, 3,985 (13.1%) had contact ulcers or ulcer scars in the mucous membranes over vocal processes and medial angles of arytenoid cartilages. The incidence was higher fed during fall than other seasons. We hypothesize: 1. that some feedlot develop acute mucositis mixed infections with species Pasteurella, Haemophilus, Mycoplasma, viruses nose, pharynx, larynx; 2. reflex coughing swallowing accelerate rate larynx closure; 3. closures erode...
RP 73401, a type IV phosphodiesterase inhibitor, caused toxic effects in the nasal olfactory region of Sprague-Dawley rats when administered by either oral or inhalation exposure. A single administration 73401 (at dose ≥50 mg/kg) 5-day exposure (1 hr/day) at approximately 1.0 mg/kg per day degeneration and sloughing surface epithelium. Degeneration loss Bowman's glands were noted underlying lamina propria submucosa. Electron microscopy these lesions demonstrated that sustentacular cells...
Activating mutations of the leucine-rich repeat kinase 2 ( LRRK2) gene are associated with Parkinson disease (PD), prompting development LRRK2 inhibitors as potential treatment for PD. However, kidney safety concerns have surfaced from knockout (KO) mice and rats repeat-dose studies in rodents administered inhibitors. To support drug this therapeutic target, we conducted a study 26 weeks’ duration 2-month-old wild-type KO Long-Evans Hooded to systematically examine performance urinary...
The preclinical safety of RPR 106541, a novel 17-thiosteroid, was evaluated in young adult and mature dogs by inhalation exposure for 26 weeks 52 weeks, respectively. A dry powder formulation 106541 lactose administered to (approximately 6 months age at initiation) doses 0 (air placebo controls), 10, 100, or 1,000 μg/kg/d weeks. solution-based aerosol 10 from pressurized metered dose inhaler 50, 150 Clinical evidence glucocorticosteroid-induced immunosuppression observed 20-26 following...
Toxicology studies in nonhuman primates were conducted to evaluate selective, brain penetrant inhibitors of LRRK2. GNE 7915 was limited 7-day administration cynomolgus monkeys at 65 mg/kg/day or 14 days rhesus 22.5 mg/kg b.i.d. due physical signs. Compound 25 demonstrated acceptable tolerability 50 and 225 for 7 monkeys. MK-1468 tolerated during 100, 200 800 30-day 30, 500 The lungs revealed hypertrophy type 2 pneumocytes, with accumulation intra-alveolar macrophages. Transmission electron...
Diabetes mellitus is a leading cause of human blindness in the United States. The major intraocular lesion responsible diabetic retinopathy. Retinal vascular changes, chiefly capillary microaneurysms, loss pericytes, obstruction and development arteriolar-venous shunts, are basis retinal disease?.'4 In spite high natural incidence diabetes dog, changes uncommon. When present, they usually consist pericyte aneurysms but progression to proliferative stage clinical appearance severe bilateral...
Immunologic responses were studied in beagle dogs following prenatal (35 days gestation) irradiation to evaluate the effects of ionizing radiation on developing immune system. Each dog received 1.5 Gy 60Co gamma or sham irradiation. Prenatally irradiated exhibited a significant reduction primary humoral antibody inoculated sheep red blood cells, T-dependent antigen, and concurrent decrease T-helper lymphocyte subpopulations peripheral at 3 4 months age. Similarly, fetuses have been shown...
Thymic explant cultures were used to study the radiosensitivity of nonlymphoid thymic components in dogs. fragments from fetal (50 days gestation), newborn, and juvenile (70 old) dogs irradiated vitro at 0, 0.5, 1, 2, or 4 Gy prior culture. Colonies classified as epithelial, spindle, mixed cell type, colony numbers counted diameters measured. Radiation caused a significant dose-related decrease number spindle colonies all ages. There was corresponding, but smaller, increase epithelial...
Friedman, M. J. D.; Blazina, E. M.D.; Fox, Pizzo, K. Del Miller, G. M.D. Author Information