Introduction: The co-occurrence of diabetes and COVID-19 infection poses a significant medical challenge due to the increased risk serious complications. Infection with SARS-CoV-2, virus responsible for COVID-19, exacerbates these risks because systemic inflammation it causes direct indirect effects on cardiovascular system. Objective: aim this study was explore in diabetic patients testing positive Pointe-Noire, Republic Congo. Methods: We recruited total 206 participants study. Biomarkers...

Background and objective: Free radical chain reaction is a condition where there an imbalance between free radicals antioxidants in the body. This can lead to cellular tissue damage, which of particular concern context cognitive decline associated with diabetes. The aim this study was identify molecular markers oxidative stress diabetic rats. Material methods: involved 24 Wistar rats, classified into 3 groups, normal (GT), untreated (DTN) treated D-erythrodihydrosphingosine (inhibitor...

Introduction: The COVID-19 pandemic has had a disproportionate impact on people with certain underlying conditions, including type 2 diabetes (T2D). It is therefore essential to identify biomarkers such as microRNAs allowing patient stratification and thus contributing better care. Objective: This study aimed analyze the profile of in diabetic patients nasopharyngeal secretions Pointe-Noire. Methods: We recruited total 206 participants for this study. Detailed information participants' age,...

Background & objective: Buruli Ulcer (BU) is a human skin infection caused by Mycobacterium ulcerans, an environmental mycobacterium. This pathology most prevalent in humid tropical regions, particularly near swampy or flood-prone areas. In Pointe-Noire, coastal city the Republic of Congo, ulcer health threat requiring ongoing surveillance and awareness-raising efforts to control its spread. The aim this study was determine prevalence ulcers patients consulting for chronic wounds...

Objectives. The HTLV-1 infection persists for life, remaining as asymptomatic viral reservoirs in most patients, ensuring the chain of transmission, but around 4% develop adult T-cell leukemia/lymphoma (ATLL). is an oncogenic retrovirus that transforms CD4+ T lymphocytes and deregulates lymphoproliferative pathways contribute to development ATLL. To achieve cell transformation, retroviruses use proto-oncogene capture transduction, with proviral integration disrupting expression tumor...

Introduction: The SARS-CoV-19 pandemic affected the whole world, with a particularly high and severe incidence in patients co-morbidities such as type 2 diabetes (T2DM). SARS-CoV-2 variants, Delta Omicron, posed an additional challenge management of these because their virulence transmissibility. Objective: To assess disturbance certain biomarkers COVID-19-positive T2DM Pointe-Noire. Methods: We performed descriptive cross-sectional study on cohort 206 diabetic by COVID-19. Blood samples...

H. pylori is a micro-aerophilic, gram-negative, S-curved, polar motility, spiral bacillus measuring 2.5 µm to 5 long and 0.3 wide. Type two diabetes of mellitus metabolic disorder characterized by chronic hyperglycemia associated with disturbances the various metabolisms, in particular lipid, carbohydrate protein. In this study, we aimed determine prevalence infection diabetic non-diabetic population consulting gastroenterology external medicine department CHU-Brazzaville. We carried out...

Background: H. pylori is a micro-aerophilic, gram-negative, spiral shaped pathogenic bacterium that specifically colonizes on the gastric epithelium and it one of most common human bacterial pathogens in wide world. Type 2 Diabetes Mellitus known as non-insulin-dependent diabetes mellitus metabolic disorder characterized by chronic hyperglycemia associated with disturbances various metabolisms, particular lipid, carbohydrate protein. Materials Methods: In this study, we aimed to determine...

Introduction: The COVID-19 pandemic has affected the whole world, with a particularly high and severe incidence in patients co-morbidities such as type 2 diabetes (T2DM). Detection of microRNAs human samples may be an alternative to identify effective biomarkers for severity. Methods: We recruited total 206 participants this study. MicroRNA variant analysis were performed on nasopharyngeal using qPCR. study consisted detection 17 microRNAs. Results: majority individuals Delta (68.18%, n=90)...

Introduction: Type 2 diabetes mellitus (T2DM) patients are at increased risk of developing a severe form COVID-19. And these Patients with COVID-19 tend to have high viral load. Objective: Identify biomarkers that show significant variation between different covid-19 load groups in T2DM Pointe-Noire. Methods: We recruited total 206 participants for this study. Detailed information on age, gender, and health status was collected from medical records. Biomarkers were quantified blood samples...

Introduction: Chronic diabetes leads to dyslipidaemia. Patients with dyslipidaemia, the most common risk factor for cardiovascular disease, also have a higher of severe evolution COVID-19. Objective: To study characteristics lipid profile disorders in COVID-19 positive type 2 diabetic patients Pointe-Noire. Methods: We recruited total 206 participants this study. Detailed information on age, gender, and health status was collected from medical records. Biomarkers were quantified blood...

Background & Objective: Schistosomiasis remains a public health problem, particularly in sub-Saharan Africa. The disease is closely linked to poverty and environmental factors. Populations who are highly exposed the fresh water of Cayo Lake on daily basis likely sustain transmission disease. It therefore necessary investigate their frequencies order combat perpetuation schistosomiasis. Methods: This was cross-sectional study carried out August 2024 around Lac Cayo, among inhabitants...

Background and objective: The study of the S1P signaling pathway in context diabetes offers a novel perspective for understanding mechanisms underlying cognitive decline developing new therapeutic strategies. Material methods: involved 24 Wistar rats, divided into three groups: group 1 was given distilled water served as control group; 2 made up rats diabetic water; 3 treated with D-erythro-dihydrosphingosine (SPK1 SPK2 inhibitor). Behavioral tests included object recognition maze tests,...

Introduction: Untreated diabetes can accelerate brain ageing and increase the risk of cognitive impairment dementia. Objective: To assess decline associated with alloxan monohydrate-induced in Wistar rats. Material methods: This study involved 24 rats weighing between 150 300 g. They were divided into three groups: (1) normal rats, (2) untreated diabetic (3) treated D-erythrodihydrosphingosine (inhibitors SPK1 SPK2). The given glucose food overnight to prevent hypoglycaemia. Behavioural...

Introduction: There has been growing interest in the biological interactions between diabetes and COVID-19, particularly because of serious implications associated with coexistence these two medical conditions. Objective: The aim this study was to identify poor prognostic factors type 2 diabetic patients COVID-19 Pointe-Noire. Methods: We recruited a total 206 participants for study. Detailed information on age, gender, health status collected from records. Biomarkers were quantified blood...

Introduction: H.pylori infection is the most common bacterial worldwide and associated with gastrointestinal diseases extra-gastrointestinal pathologies such as diabetes mellitus insulin resistance. Objective: To evaluate resistance in diabetics non-diabetics infected H. pylori. Methods: We conducted a descriptive cross-sectional study. 90 patients were selected divided into two groups, 44 T2DM 46 non-diabetic patients. All information concerning age sex of subjects was collected from...

Background: Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of beta cells in pancreatic islets Langerhans. This study aimed to investigate T lymphocyte pathway involved cytomegalovirus (CMV) infection T1D patients context of. Pointe Noire Method: We conducted analytical case-control over 6 months between June and November 2022. A total 234 subjects were enrolled, including 68 (T1D +CMV+) cases, 62 +CMV-) 104 healthy as control group (healthy controls). The...

Viral infections are one of the triggers and aggravators factors type 1 diabetes (T1D) development. Among these infections, human cytomegalovirus infection affects 60-90% world’s population. The aim this study was to describe metabolic consequences Cytomegalovirus in T1D subjects. We conducted a descriptive cross-sectional over 6 months between June November 2021. A total 72 subjects were enrolled. following laboratory tests performed: fasting blood glucose, HbA1c, C peptide, lipid profile...