A5022086101- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing and 3D Printing Technologies
There is critical need for a predictive model of human cardiac physiology in drug development to assess compound effects on tissues. In vitro two-dimensional monolayer cultures cardiomyocytes provide biochemical and cellular readouts, vivo animal models information systemic cardiovascular response. However, there remains significant gap these due their incomplete recapitulation adult physiology. Recent efforts developing from engineered heart tissues have demonstrated potential bridging this...
ABSTRACT There is critical need for a predictive model of human cardiac physiology in the drug development process assessment compound toxicology and pharmacology. In vitro two-dimensional monolayer culture cardiomyocytes provides biochemical cellular readouts, vivo small large animal models provide information on systemic cardiovascular response. However, there remains significant gap these due to an incomplete recapitulation adult physiology, which results more difficult safety...