A5069852073- RNA Research and Splicing
- RNA modifications and cancer
- Microbial Metabolic Engineering and Bioproduction
- Monoclonal and Polyclonal Antibodies Research
- Transgenic Plants and Applications
- RNA regulation and disease
- Bioinformatics and Genomic Networks
- Trace Elements in Health
- Protein Structure and Dynamics
- CRISPR and Genetic Engineering
Brunel University of London
2024
Ontario Genomics
2023
Abstract Accurately modeling and predicting RNA biology has been a long-standing challenge, bearing significant clinical ramifications for variant interpretation the formulation of tailored therapeutics. We describe foundation model biology, “BigRNA”, which was trained on thousands genome-matched datasets to predict tissue-specific expression, splicing, microRNA sites, binding protein specificity from DNA sequence. Unlike approaches that are restricted missense variants, BigRNA can identify...
Abstract Motivation Computational methods to detect correlated amino acid positions in proteins have become a valuable tool predict intra- and inter-residue protein contacts, structures, effects of mutation on stability function. While there are many tools webservers compute coevolution scoring matrices, is no central repository alignments matrices for large-scale studies pattern detection leveraging biological structural annotations already available UniProt. Results We present Python...
<title>Abstract</title> Accurately modeling and predicting RNA biology has been a long-standing challenge, bearing significant clinical ramifications for variant interpretation the formulation of tailored therapeutics. We describe foundation model biology, “BigRNA”, which was trained on thousands genome-matched datasets to predict tissue-specific expression, splicing, microRNA sites, binding protein specificity from DNA sequence. Unlike approaches that are restricted missense variants,...