A5064592125- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Radiomics and Machine Learning in Medical Imaging
- RNA Interference and Gene Delivery
- Animal Virus Infections Studies
- Advancements in Transdermal Drug Delivery
- Memory and Neural Mechanisms
- Lipid Membrane Structure and Behavior
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Screening and Detection
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
Bio-Medical Science (South Korea)
2020-2025
Korea Institute of Science and Technology
2020-2025
University of Science and Technology
2025
Korea University of Science and Technology
2020-2025
Korean Association Of Science and Technology Studies
2025
Korea Institute of Brain Science
2020
The rapid development of messenger RNA (mRNA) vaccines formulated with lipid nanoparticles (LNPs) has contributed to control the COVID-19 pandemic. However, mRNA have raised concerns about their potential toxicity and clinical safety, including side effects, such as myocarditis, anaphylaxis, pericarditis. In this study, we investigated trehalose glycolipids-containing LNP (LNP S050L) reduce risks associated ionizable lipids. Trehalose glycolipids can form hydrogen bonds polar biomolecules,...
The extracellular matrix (ECM) is a complex network of biomolecules with varying pore sizes, posing challenge for the effective penetration lipid nanoparticles. In contrast, cell-derived nanoparticles, such as exosomes, have demonstrated ability to travel distant organs, indicating their capacity penetrate ECM. Here, we designed exosome-like vesicles (ELVs) inspired by exosomes' distinct transport phenomena. Specifically, integrated three exosomal components (anionic lipid, cholesterol, and...
Bladder cancer, when diagnosed at an advanced stage, often necessitates inevitable invasive intervention. Consequently, non-invasive biosensor-based cancer detection and AI-based precision screening are being actively employed. However, the misclassification of patients as normal-referred to false negatives-remains a significant concern, it could lead fatal outcomes in lifespan. Moreover, while ensemble techniques such soft voting other methods can improve model accuracy reduce...
Abstract Introduction Densin‐180 interacts with postsynaptic molecules including calcium/calmodulin‐dependent protein kinase IIα (CaMKIIα) but its function in learning and memory process has been unclear. Methods To investigate a role of hippocampal densin‐180 contextual fear conditioning (CFC) processes, knockdown (KD) subareas was applied. Results First, ventral (vHC) KD impaired single‐trial CFC (stCFC) one day later. stCFC caused freezing behaviors to reach the peak about hour later both...