A5007277800- Veterinary Oncology Research
- Sarcoma Diagnosis and Treatment
- Cancer Research and Treatments
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
- Angiogenesis and VEGF in Cancer
- Chemokine receptors and signaling
- interferon and immune responses
- Click Chemistry and Applications
- Immunotherapy and Immune Responses
- Antimicrobial Peptides and Activities
University of Illinois Urbana-Champaign
2022-2023
Here, an in vitro characterization of a family prazole derivatives that covalently bind to the C73 site on Tsg101 and assay their ability inhibit viral particle production is presented. Structurally, increased steric bulk 4-pyridyl expands UEV domain toward β-hairpin Ub-binding coupled inhibition virus-like HIV-1. Increased also toxicity, which alleviated by increasing flexibility. Further, formation novel secondary adduct for several tested compounds commercial drug lansoprazole. The...
Cytokine therapies such as IL2 and IL12 suffer from impractically small therapeutic windows driven by their on-target, off-tumor activity, limiting clinical potential despite potent antitumor effects. We previously engineered cytokines that bind anchor to tumor collagen following intratumoral injection, sought test safety biomarker activity in spontaneous canine soft-tissue sarcomas (STS).Collagen-binding were canine-ized minimize immunogenicity used a rapid dose-escalation study healthy...
<p>Supplementary Methods S1</p>
<p>Pathway scores from canine Nanostring nSolver analysis</p>
<p>Pathway scores from mouse Nanostring nSolver analysis</p>
<p>IFN-γ and IL-10 individual replicates from Milliplex, healthy beagles</p>
<p>Patient tumor images and cohorts</p>
<p>IFN-γ and IL-10 individual replicates from Milliplex, sarcoma patients</p>
<p>PAX5 immunohistochemistry</p>
<p>Collagen-binding ELISA comparison to prior mouse constructs</p>
<p>Supplementary Methods S1</p>
<p>Pathway scores from mouse Nanostring nSolver analysis</p>
<div>Abstract<p>Purpose: Cytokine therapies such as interleukin-2 and -12 suffer from impractically small therapeutic windows driven by their on-target, off-tumor activity, limiting clinical potential despite potent antitumor effects. We previously engineered cytokines that bind anchor to tumor collagen following intratumoral injection, sought test safety biomarker activity in spontaneous canine soft tissue sarcomas (STS). Methods: Collagen-binding were canine-ized minimize...
<p>PAX5 immunohistochemistry</p>
<p>Pathway scores from canine Nanostring nSolver analysis</p>
<p>Collagen-binding ELISA comparison to prior mouse constructs</p>
<p>Patient tumor images and cohorts</p>
<p>IFN-γ and IL-10 individual replicates from Milliplex, sarcoma patients</p>
<p>IFN-γ and IL-10 individual replicates from Milliplex, healthy beagles</p>