A5005550672- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Histone Deacetylase Inhibitors Research
- Muscle Physiology and Disorders
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Multiple Myeloma Research and Treatments
- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Evaluation
- RNA Research and Splicing
- Marine Invertebrate Physiology and Ecology
- RNA modifications and cancer
- Cancer-related gene regulation
- Antifungal resistance and susceptibility
- Marine Sponges and Natural Products
University of Bonn
2024-2025
GEOMAR Helmholtz Centre for Ocean Research Kiel
2023
Translational Genomics Research Institute
2022-2023
Targeted protein degradation (TPD) represents a promising alternative to conventional occupancy-driven inhibition. Despite the existence of more than 600 E3 ligases in human proteome, so far only few have been utilized for TPD histone deacetylases (HDACs), which represent important epigenetic anticancer drug targets. In this study, we disclose first-in-class Fem-1 homologue B (FEM1B)-recruiting HDAC degraders. A set 12 proteolysis targeting chimeras (PROTACs) was synthesized using...
Proteolysis-targeting chimeras (PROTACs) have recently gained popularity as targeted protein degradation (TPD) promises to overcome the limitations of occupancy-driven pharmacology. However, most degraders rely on a small number E3 ligases. In this study, we present first-in-class histone deacetylase (HDAC) PROTACs recruiting DDB1- and CUL4- associated factor 11 (DCAF11). We established synthesis route entirely solid-phase prepare set eleven degraders. The long flexible spacer bearing FF2039...
Proteolysis-targeting chimeras (PROTACs) have recently gained popularity as targeted protein degradation (TPD) promises to overcome the limitations of occupancy-driven pharmacology. However, most degraders rely on a small number E3 ligases. In this study, we present first-in-class histone deacetylase (HDAC) PROTACs recruiting DDB1- and CUL4- associated factor 11 (DCAF11). We established synthesis route entirely solid-phase prepare set eleven degraders. The long flexible spacer bearing FF2039...
Proteolysis‐targeting chimeras (PROTACs) have recently gained popularity as targeted protein degradation (TPD) promises to overcome the limitations of occupancy‐driven pharmacology. However, most degraders rely on a small number E3 ligases. In this study, we present first‐in‐class histone deacetylase (HDAC) PROTACs recruiting DDB1‐ and CUL4‐ associated factor 11 (DCAF11). We established synthesis route entirely solid‐phase prepare set eleven degraders. The long flexible spacer bearing FF2039...
The body muscle is an important tissue used in organisms for proper viability and locomotion. Although this generally well studied characterized, many pathways have been elucidated throughout the years, we still lack a comprehensive understanding of its transcriptome how it controls development function. Here, updated nuclear FACS sorting-based methodology to isolate sequence high-quality from Caenorhabditis elegans mixed-stage animals. We identified 2848 muscle-specific protein-coding...
The widespread and irrational use of azole antifungal agents has led to an increase azole-resistant
The marine mesopelagic zone extends from water depths of 200 m to 1000 and is home a vast number diversity species. It one the least understood regions environment with untapped resources pharmaceutical relevance. jellyfish Periphylla periphylla well-known widely distributed species in zone; however, or potential its cultivable microbiota has not been explored. In this study, we isolated microorganisms associated inner outer umbrella P. collected Irminger Sea by culture-dependent approach,...
Targeted protein degradation (TPD) represents a promising alternative to conventional occupancy-driven inhibition. Despite the existence of more than 600 E3 ligases in human proteome, so far only few have been utilized for TPD histone deacetylases (HDACs), which represent important epigenetic anticancer drug targets. In this study, we disclose first-in-class Fem-1 homolog B (FEM1B)-recruiting HDAC degraders. A set twelve proteolysis targeting chimeras (PROTACs) was synthesized using...
ABSTRACT The body muscle is an important tissue used in organisms for proper viability and locomotion. Although this generally well studied characterized, many pathways have been elucidated throughout the years, we still lack a comprehensive understanding of its transcriptome how it controls development function. Here, updated nuclear FACS sorting-based methodology to isolate sequence high-quality from C. elegans mixed-stage animals. We identified 2,848 muscle-specific protein-coding genes,...