For adults, disability produced by migraines has been assessed with a migraine-specific tool-MIDAS. The objective of this study was to develop and validate similar tool that accurately depicts the headaches in school-age children adolescents.A six-question (PedMIDAS) developed administered patients attending tertiary referral center for pediatric headaches. Internal consistency test/retest reliability were assessed. Validity correlating scores headache frequency, severity, duration. Changes...

Early, safe, effective, and durable evidence-based interventions for children adolescents with chronic migraine do not exist.

Background.—Coenzyme Q10 (CoQ10) has been suggested to be effective in the prevention of migraine, and levels can quantified with standardized reference ranges. Objective.—This study documents prevalence CoQ10 deficiency migraine headache examines potential effectiveness supplementation. Methods.—We assessed patients attending a tertiary care center frequent headaches for deficiency. We recommended low begin supplementation as part their multidisciplinary treatment plan. response including...

Objective: To evaluate the efficacy of Coenzyme Q10 (CoQ10) supplementation in prevention migraine children using a placebo-controlled, double-blinded, crossover, add-on trial. Background: CoQ10 has been demonstrated to have adults but lacks pediatric research with more rigorous methodology. observed be deficient significant number and adolescents presenting tertiary headache centers. potential modify both inflammatory changes that occur during recurrent alteration mitochondrial function. A...

Background.—Migraine is a significant problem for many children. Topiramate has been suggested to be effective the prophylaxis of migraine in adults, but not yet examined The drug demonstrated safe and childhood seizure disorders. objective this study was demonstrate safety efficacy topiramate prevention pediatric migraine. Methods.—Children with frequent were prescribed headache prevention. Dosages, serum levels, Serum Glutamic Oxalacetic Transaminase (SGOT) levels monitored. Changes...

To assess the effectiveness of aggressive therapy status migraine in children and adolescents.Inpatient management pediatric intractable headache is limited because a lack studies guidelines. Adult treatment often based on anecdotal experience, although few controlled have been reported. Added to that discomfort general pediatricians neurologists using available effective treatments patients (such as dihydroergotamine: DHE).Charts all admitted neurology service, at Cincinnati Children's...

Chronic pain in children is associated with significant negative impact on social, emotional, and school functioning. Previous studies the of children's functioning have primarily used mixed samples conditions or single (eg, headache abdominal pain) relatively small sample sizes. As a result, similarities differences subgroups chronic not been closely examined.

The objective of this secondary analysis results from a previously published trial (Clinical Trials Registration Number: NCT00389038) in chronic migraine children and adolescents was to examine if participants who received cognitive behavioral therapy amitriptyline reached greater level reduction headache frequency that no longer indicated recommendation for preventive treatment as compared those education amitriptyline.Chronic negatively affects children's home, school, social activities....

<b><i>Background:</i></b> Chronic daily headaches (CDH) occur in &gt;4% of the adult population. The criteria for CDH, however, are controversial. In children, characterization frequent and CDH is limited. <b><i>Methods:</i></b> A Headache Center to characterize children (3 18 years old) was established. Over 34 months, 577 have been evaluated. With use a definition ≥15 per month, 200 (34.6%) had CDH. <b><i>Results:</i></b> average age at first headache these 9.3 ± 3.6 years, whereas...

The objectives of this study were to assess comorbid psychiatric diagnoses in youth with chronic daily headache (CDH) and examine relationships between status CDH symptom severity, as well headache-related disability.Standardized interviews (Kiddie Schedule for Affective Disorders Schizophrenia, KSADS) conducted 169 ages 10-17 diagnosed CDH. Participants provided prospective reports frequency a diary completed measures disability (PedMIDAS) quality life (PedsQL).Results showed that 29.6%...

Objective. To study the effectiveness of prochlorperazine in aborting severe, intractable migraines children. Study Design. Patients for this were drawn from population seen and evaluated Headache Center at Cincinnati Children's Hospital Medical Center. All patients diagnosed with migraine headache by both clinical International Society criteria. The intravenous 20 consecutive referred to emergency department prolonged was retrospectively reviewed. Results. presented a mean severity 8.4 on...

To characterize menstrually associated headaches and migraine in adolescent girls identify any developmental pubertal changes.Headache is a common problem adolescents with transition to adult patterns. One pattern of the menstrual association significant number women.A retrospective analysis was performed characteristics adolescent's including pattern. A detailed patient- parent-reported headache patterns longitudinal change development puberty reviewed, timing age period progression these...

Objective The purpose of this investigation was to examine treatment adherence medication and lifestyle recommendations among pediatric migraine patients using electronic monitoring systems. Background Nonadherence medical is a significant public health concern, can result in poorer outcomes, decreased cost‐effectiveness care, increased morbidity. No studies have systematically examined adolescents with outside clinical trial. Methods Participants included 56 ages 11‐17 who were presenting...

To assess the long-term effectiveness and outcome of multidisciplinary treatment childhood headaches 1, 2, 5 years after initial treatment.Headaches are a common problem for children adolescents many patients continue into adulthood. Outcome research pediatric migraine is limited, thus restricting knowledge management outcome.Headache characteristics were assessed at visit reevaluated later in independent sub-groups consecutive patients. These included headache frequency, severity, average...

Biopsychosocial treatment response among youth with continuous headache: A retrospective, clinic‐based study,

To examine treatment adherence among children and adolescents with chronic migraine who volunteered to be in a clinical trial using 3 measures: session attendance, therapy homework completion, preventive medication use by daily diary.

Objective.—To assess the tolerability and effectiveness of nasal sumatriptan in treatment migraine 5‐ to 12‐year‐old children. Background.—Although headaches are a common disorder occur up 10.6% children, many new abortive agents have not been well evaluated this population. It has recently reported that is effective adolescents. In younger it yet be characterized. addition, children significant amounts vomiting with their migraines, limiting use oral medications. Design Methods.—Children...

Recent studies have raised significant concern about the high prevalence of childhood abuse in adults with chronic daily headache (CDH). In a survey 1348 adult migraine patients,1 it was found that 21% patients reported history physical and 25% sexual abuse. Data from ACE (Adverse Childhood Experiences) study other also forms maltreatment were significantly associated headache.2–4 Although retrospective seem to provide strong evidence for an association between CDH, one prospective...

To evaluate factors that influence migraine recurrence after outpatient infusion or inpatient treatment for intractable migraine.Recurrence of acute in an center setting is not well documented children and adolescents. Given the multifactorial pathogenesis migraines, multiple may recurrence. It has been reported with steroids reduce risk The efficacy as a therapeutic adjunct established. Studies adult population have yielded conflicting results.This study retrospective chart review patients...

Objectives To characterize the short‐term prognosis of a clinical population pediatric and young adult patients with migraine explore predictors worsening while in care. Methods This was retrospective study all seen at Cincinnati Children’s Hospital Headache Center from 09/01/2006 to 12/31/2017, who had least 1 follow‐up visit within 1‐3 months index analyzed. Included data were: age, sex, race, primary ICHD diagnosis, chronic migraine, medication overuse, history status migrainosus, BMI...

Background.—Migraine headache is common and has multiple etiologies. A number of mitochondrial anomalies have been described for migraine, dysfunction implicated as one potential pathophysiological mechanism. Carnitine used by mitochondria fatty acid transportation; its deficiency, however, not in migraine pathophysiology. Methods Results.—Two adolescent girls presented to the Headache Center at Cincinnati Children's Hospital Medical with frequent headaches were diagnosed International...

Background Fifty-three percent of adolescent girls report headaches at the onset menses, suggesting fluctuations ovarian hormones trigger migraine during puberty. Aims To determine if urinary metabolites estrogen and progesterone are associated with days headache (HO) or severity in migraine. Methods This was a pilot study included 34 balanced across three age strata (pre-pubertal (8–11), pubertal (12–15), post-pubertal (16–17) years age). They collected daily urine samples recorded...

Objectives To characterize a population of pediatric patients visiting an infusion center for acute migraine and determine predictors first‐line treatment success in this population. Background Though is common the emergency department specialized centers, little known about patient whether or not clinical data can be used to predict response. Methods This was observational study involving retrospective analysis from visits Cincinnati Children's Hospital migraine. Data were extracted...