A5093064275- RNA modifications and cancer
- RNA Research and Splicing
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- HIV Research and Treatment
- interferon and immune responses
- HVDC Systems and Fault Protection
- Cancer-related molecular mechanisms research
- Insect symbiosis and bacterial influences
Universitat Pompeu Fabra
2023-2024
Robert Koch Institute
2021
Abstract Despite the nuclear localization of m 6 A machinery, genomes multiple exclusively-cytoplasmic RNA viruses, such as chikungunya (CHIKV) and dengue (DENV), are reported to be extensively A-modified. However, these findings mostly based on A-Seq, an antibody-dependent technique with a high rate false positives. Here, we address presence in CHIKV DENV RNAs. For this, combine A-Seq antibody-independent SELECT nanopore direct sequencing techniques functional, molecular, mutagenesis...
Abstract Background The genomes of HIV-2 and some SIV strains contain the accessory gene vpx , which carries out several functions during infection, including downregulation SAMHD1. Vpx is also commonly used in experiments to increase HIV-1 infection efficiency myeloid cells, particularly studies that investigate activation antiviral pathways. However, potential effects on cellular innate immune signaling not completely understood. We investigated whether how affects ISG responses monocytic...
Arboviruses pose a significant threat to public health globally, demanding innovative approaches for their control. For this, better understanding of the complex web interactions established in arbovirus-infected mosquitoes is fundamental. High-throughput analyses allow genome-wide view arbovirus-induced alterations at different gene expression levels. This review provides comprehensive perspective into current literature transcriptome and proteome landscapes infected with arboviruses. It...
Abstract Despite the nuclear localization of m 6 A machinery, genomes multiple exclusively-cytoplasmic RNA viruses, such as chikungunya (CHIKV) and dengue (DENV), are reported to be extensively A-modified. However, these findings mostly based on A-seq, an antibody-dependent technique with a high rate false positives. Here, we addressed presence in CHIKV DENV RNAs. For this, combined A-seq antibody-independent SELECT nanopore direct sequencing techniques functional, molecular, mutagenesis...