Given the prevalence of nitrogen-containing heterocycles in commercial drugs, selectively incorporating a single nitrogen atom is promising scaffold hopping approach to enhance chemical diversity drug discovery libraries. We harness distinct reactivity sulfenylnitrenes, which insert transform readily available pyrroles, indoles, and imidazoles into synthetically challenging pyrimidines, quinazolines, triazines, respectively. Our additive-free method for skeletal editing employs easily...

A straightforward Rh(<sc>iii</sc>)-catalyzed general strategy was developed for the introduction of naphthol/phenol moieties to 8-methyl and formylquinolines using diazonaphthalen-2(1<italic>H</italic>)-ones/quinone diazides.

Given its earth abundance, cost-effectiveness, and ecofriendly qualities, iron serves as a promising alternative to precious metals in catalysis. This article presents an carbene-initiated cascade approach for synthesizing highly substituted tetrahydrofurans at the gram scale. reaction utilizes readily accessible β-hydroxyketones diazo compounds works with catalyst loading low 5 mol %. proceeds through O–H insertion into diazo-derived carbenes, followed by intramolecular aldol access...

Abstract An efficient Rh III ‐catalyzed redox‐neutral method for the direct C8‐arylation of quinoline N ‐oxides using diazonaphthalen‐2(1 H )‐one as coupling partner has been demonstrated. The developed is simple, scalable and straightforward with a wide range substrate scope. applicative potential was extended late‐stage functionalization synthesis 8‐azaBINOL derivative. A plausible reaction pathway proposed after carrying out preliminary control studies.

1,2-cis-Furanosides are present in various biomedically relevant glycosides, and their stereoselective synthesis remains a significant challenge. In this vein, we have developed approach to 1,2-cis-furanosylations using earth-abundant copper catalysis. This protocol proceeds under mild conditions at room temperature employs readily accessible benchtop stable enynal-derived furanose donors. chemistry accommodates variety of alcohols, including primary, secondary, tertiary, as well mannosyl...

Spirulina, a blue-green microalga, is high in protein, vitamins, minerals and antioxidants, making it popular supplement for improving general health. Due to its potentiality fat metabolism, the study aims explore effect of eight weeks Spirulina supplementation reducing body overweight young males. Following CONSORT 2010 checklist, eight-week placebo-controlled trial has been implemented involving twenty participants. The experimental group received 5 grams weeks. intake frequency increased...

In this study, we harness the distinct reactivity of sulfenylnitrenes, which insert a single nitrogen atom to transform readily available pyrroles, indoles, and imidazoles into synthetically challenging pyrimidines, quinazolines, triazines, respectively. Our additive-free method for skeletal editing employs easily accessible, benchtop-stable sulfenylnitrene precursors as source atom. This chemical approach is compatible with free diverse functional groups, including oxidation-sensitive...

Abstract Herein, we present an approach for catalytic orthogonal glycosylation utilizing earth‐abundant copper carbenes. This method operates under mild conditions and employs readily accessible starting materials, including benchtop stable enynal‐derived glycosyl donors, synthesized at the gram scale. The reaction accommodates a variety of acceptors, primary, secondary, tertiary alcohols. carbenes exhibit remarkable reactivity selectivity, allowing formation glycosidic linkages with...

Thioglycoside activation, crucial for oligosaccharide synthesis, faces challenges with the need stoichiometric promoters, additives, and cryogenic conditions, particularly in stereoselective 1,2-cis-linkage formation. This study introduces a carbene-based catalytic method using Cu(OTf)2 thioglycoside enabling efficient 1,2-cis-furanosylation ribose arabinose. The is orthogonal to conventional alkyne donors, accommodates sterically demanding acceptors, achieves stereoselectivity independent...

This study introduces a cascade approach that proceeds with an N–H insertion into enynal-derived zinc–carbenoid, followed by intramolecular aldol reaction to provide (2-furyl)-2-pyrrolidines high diastereoselectivity (dr ≥ 98:2).

ISHS III WOCMAP Congress on Medicinal and Aromatic Plants - Volume 2: Conservation, Cultivation Sustainable Use of PERFORMANCE OF ALOE VERA AS INFLUENCED BY ORGANIC AND INORGANIC SOURCES FERTILIZER SUPPLIED THROUGH FERTIGATION

A study was conducted to evaluate the changes in total calcium and sulphur some heavy metal (Zn, Cu, Pb) concentration of different organic wastes affected by liming microorganism inoculation. Vermicomposting an effective technology for disposal substrates like municipal solid (MSW), possessing comparatively higher metals. The addition lime initial significantly (P ≤ 0.05) increased content vermicomposts. Inoculation microorganisms reduced final products as compared control. Fungal strains...

SUMMARY In an intermediate deepwater (15–50 cm) situation, the number of tillers increased with increase nitrogen fertilizer from 0 to 40 and 80 kg/ha seed rate 100 200, 300 400 seeds/m 2 . The tiller mortality due higher water depth was under no-N treatment rates. panicles grain yield significantly in N. Similarly, decreased grains per panicle weight. yields different rates were similar. interaction between N levels not significant.

The potential for using crop wastes as a source of nutrients on the yields rice grown under submerged conditions was studied in both field and pot experiments at Experimental Farm Agricultural Food Engineering Department, Indian Institute Technology, Kharagpur during 1992/93 1993/94. application groundnut haulm 3·0 t/ha, maize stover 5·0 mustard t/ha green manure 1·5 contributed considerable amounts nutrients, which improved components yield, yield nutrient uptake by also organic carbon (OC)...

The reaction of 3-nucleofugal phthalides with 2-amidoacrylates is shown to provide a synthesis densely substituted naphth[2,1-<i>d</i>]oxazoles in good yields. It proposed proceed via five-step cascade which includes phthalide annulation, demethoxycarbonylation, and heterocyclization. methodology free from regiochemical ambiguity the products. In certain cases, corresponding 2-amidonaphthoquinones are directly formed.

Enantioselective organocatalytic Michael addition reactions of 1-acetylcyclohexene, 1-acetylcyclopentene and 1-acetylcyclobutene to nitroolefins have been developed. This is the first report where an α-branched enone has activated by amine catalyst for asymmetric reaction electrophile. The products also cyclized bicyclic compounds.

Abstract Nitrogen and weeds are two important factors that influence the productivity of rainfed upland rice ( Oryza sativa L.) in tropical Asia. A low recovery applied fertilizer N uplands is generally associated with high nitrate leaching losses weed interferences. Field experiments were conducted during wet seasons 2002 2003 at research farm Central Rainfed Upland Rice Research Station, Hazaribag, Jharkhand, India, to determine response nitrogen 60 kg ha –1 as different forms urea (single...