A5019179474- Cellular transport and secretion
- SARS-CoV-2 and COVID-19 Research
- Phagocytosis and Immune Regulation
- Influenza Virus Research Studies
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Retinal Development and Disorders
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Advanced Fluorescence Microscopy Techniques
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
Hangzhou Medical College
2025
Jiangjin Central Hospital
2023
Hebei North University
2023
University of Michigan–Ann Arbor
2022
Abstract The COVID-19 pandemic is caused by SARS-CoV-2, an enveloped RNA virus. Despite extensive investigation, the molecular mechanisms for its assembly and secretion remain largely elusive. Here, we show that SARS-CoV-2 infection induces global alterations of host endomembrane system, including dramatic Golgi fragmentation. virions are enriched in fragmented Golgi. Disrupting function with small molecules strongly inhibits viral infection. Significantly, down-regulates GRASP55 but...
Protein-protein interactions (PPIs) form complex networks to drive cellular signaling and functions. Precise modulation of a target PPI helps explain the role in events possesses therapeutic potential. For example, valosin-containing protein (VCP/p97) is hub that interacts with more than 30 adaptor proteins involved various However, each p97 during relevant event underexplored. The development small-molecule modulators remains challenging due lack grooves pockets relatively large interface...
The efficacy of immunotherapy for non-small cell lung cancer (NSCLC) is limited owing to cold tumors and drug resistance. Therefore, it important identify the molecular mechanisms underlying immune evasion in NSCLC. Spontaneous ferroptosis neutrophils has been suggested as a key mechanism immunosuppression cancer. Insulin-like growth factor binding protein 1 (IGFBP1) plays an role infiltration several cancers. However, IGFBP1 NSCLC unknown. this study, we aimed investigate association mRNA...