A5091924027- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Topic Modeling
- Machine Learning in Materials Science
- Computational Drug Discovery Methods
University of California, Los Angeles
2023
We report a visible-light photoredox-catalyzed method that enables nucleophilic amination of primary and secondary benzylic C(sp3)-H bonds. A novel amidyl radical precursor organic photocatalyst operate in tandem to transform bonds into carbocations via sequential hydrogen atom transfer (HAT) oxidative radical-polar crossover. The resulting carbocation can be intercepted by variety N-centered nucleophiles, including nitriles (Ritter reaction), amides, carbamates, sulfonamides, azoles, for...
We report a visible-light photoredox-catalyzed method that enables nucleophilic amination of primary and secondary benzylic C(sp3)–H bonds. A novel amidyl radical precursor organic photocatalyst operate in tandem to transform bonds into carbocations via sequential hydrogen atom transfer (HAT) oxidative radical-polar crossover (ORPC). The resulting carbocation can be intercepted by variety N centered nucleophiles, including nitriles (Ritter reaction), amides, carbamates, sulfonamides, azoles...