A5082784408- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Mast cells and histamine
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Xenotransplantation and immune response
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Patient-Provider Communication in Healthcare
- Immune responses and vaccinations
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Artificial Intelligence in Healthcare and Education
- Urologic and reproductive health conditions
- Renal cell carcinoma treatment
- Economic and Financial Impacts of Cancer
Uniformed Services University of the Health Sciences
2021-2024
Henry M. Jackson Foundation
2012-2024
Jackson Foundation
2012-2021
Walter Reed National Military Medical Center
2013-2021
Walter Reed Army Institute of Research
2008-2010
Armed Forces Institute of Pathology
2008-2010
No AccessJournal of UrologyAdult Urology1 Nov 2008PCA3 Score Before Radical Prostatectomy Predicts Extracapsular Extension and Tumor Volumeis accompanied byThe Significance Monoamine Oxidase-A Expression in High Grade Prostate Cancer Eric J. Whitman, Jack Groskopf, Amina Ali, Yongmei Chen, Amy Blase, Bungo Furusato, Gyorgy Petrovics, Mona Ibrahim, Sally Elsamanoudi, Jennifer Cullen, Isabell A. Sesterhenn, Stephen Brassell, Harry Rittenhouse, Shiv Srivastava, David G. McLeod WhitmanEric...
Study Type – Prognosis (retrospective cohort) Level of Evidence 2b What’s known on the subject? and What does study add? Patients who develop biochemical (PSA) recurrence after prostatectomy may subsequently metastases leading to their eventual death. However, many such patients receive additional therapies before developing metastases, so natural history disease progression in these is poorly described. We aimed report metastasis‐free survival overall for using a multicentre database....
Prostate cancer patients diagnosed with low- and intermediate-risk disease have several treatment options. Decisional regret after is a concern, especially when poor oncologic outcomes or declines in health-related quality of life (HRQoL) occur. This study assessed determinants longitudinal decisional prostate attending multidisciplinary clinic treated radical prostatectomy (RP), external beam radiation therapy (EBRT), brachytherapy (BT), active surveillance (AS).Patients newly at the Walter...
Prevalent gene fusions in prostate cancer involve androgen-regulated promoters (primarily TMPRSS2) and ETS transcription factors (predominantly ETS-regulated (ERG)], which result tumor selective overexpression of ERG two thirds patients. Because diverse genomic fusion events lead to cancer, we reasoned that it may be more practical capture such alterations using an assay targeting sequences retained fusions. This study evaluates the potential quantitating mRNA post-digital rectal exam (DRE)...
Introduction:In this review, the International Agency for Research on Cancer's cancer epidemiology databases were used to examine prostate (PCa) age-standardized incidence rates (ASIR) in selected Asian nations, including Cancer Incidence Five Continents (CI5) and GLOBOCAN databases, an effort determine whether ASIRs are rising regions of world with historically low risk PCa development.Materials Methods: nations adequate data quality considered review.PCa ASIR estimates from CI5 2008 public...
The Gleason score is an important predictor of prognosis in prostate cancer. However, its subjective nature can result over- or under-grading. Our objective was to train artificial intelligence (AI)-based algorithm grade cancer specimens from patients who underwent radical prostatectomy (RP) and assess the correlation AI-estimated proportions different patterns with biochemical recurrence-free survival (RFS), metastasis-free (MFS), overall (OS). Training validation algorithms for detection...
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES STUDY ADD?: Little is known as to the potential for over-treatment of young men diagnosed with prostate cancer. We show that aged ≤55 years PSA screen-detected disease, 45% tumours are classified very low risk and 85% these have favourable pathology, yet most actively treated. These findings raise spectre a group likely be affected by treatment side-effects.To identify population (aged <55 at diagnosis) very-low-risk cancer (stage cT1c,...
The objective of this study was to assess the incidence circulating tumor cells (CTCs) in prostate cancer patients with low-volume tumors (less than 0.5 cc) after radical prostatectomy (RP). Blood samples were collected from 64 RP CTCs following RP. specimens processed by whole-mount section. Clinicopathological data (e.g. patient age, race, specimen weight, volume, grade, stage and surgical margin status) follow-up PSA compared CTC status. Of patients, nine had ‘low-volume cancer’. Seven...
You have accessJournal of Urology1 Apr 2009RACE, TREATMENT CHOICE, AND HEALTH-RELATED QUALITY OF LIFE IN PATIENTS UNDERGOING COUNSELING FOR PROSTATE CANCER Kimberly Peay, Sally Elsamanoudi, Robin Lockhart, Susan Hogue, Thomas E Novak, and Stephen A Brassell PeayKimberly Peay , ElsamanoudiSally Elsamanoudi LockhartRobin Lockhart HogueSusan Hogue NovakThomas Novak BrassellStephen View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60084-7AboutPDF ToolsAdd to favoritesDownload...
Elucidating the cellular immune components underlying aggressive prostate cancer, especially among African American (AA) men who are disproportionately affected by this disease compared with Caucasian (CA) men, will support more inclusive precision medicine treatment strategies. We aimed to evaluate which immune-related genes and cell types differentially expressed in AA tumors how immunobiology impacts cancer progression. purified nucleic acid from tumor biopsies, obtained following radical...
Localized prostate cancer (PCa) treatment is associated with reduced health-related quality of life (HRQoL). Current literature limited by short-term follow-up.To prospectively evaluate the 5-yr HRQoL outcomes in men undergoing radical prostatectomy (RP), external beam radiotherapy (EBRT), or active surveillance (AS).We evaluated patients low-risk/favorable intermediate-risk PCa enrolled Center for Prostate Disease Research multicenter database between 2007 and 2017.Of 1012 included study,...
You have accessJournal of UrologyProstate Cancer: Localized IV1 Apr 2015PD34-08 TREATMENT DECISION-MAKING PATTERNS AMONG LOW RISK PROSTATE CANCER PATIENTS MANAGED ON ACTIVE SURVEILLANCE IN AN EQUAL ACCESS HEALTH CARE SETTING Daniel Kim, Lauren Hurwitz, Jennifer Cullen, Jane Hudak, Maryellen Colston, Judith Travis, Sally Elsamanoudi, and Inger Rosner KimDaniel Kim More articles by this author , HurwitzLauren Hurwitz CullenJennifer Cullen HudakJane Hudak ColstonMaryellen Colston TravisJudith...
You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History III1 Apr 2015MP14-05 A PROSPECTIVE COHORT STUDY OF TREATMENT DECISION-MAKING FOR PROSTATE CANCER FOLLOWING PARTICIPATION IN MULTI-DISCIPLINARY CLINIC Lauren Hurwitz, Jennifer Cullen, Sally Elsamanoudi, Daniel Kim, Jane Hudak, Maryellen Colston, Judith Travis, Huai-Ching Kuo, and Inger Rosner HurwitzLauren Hurwitz More articles by this author , CullenJennifer Cullen ElsamanoudiSally Elsamanoudi KimDaniel Kim...
You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History I1 Apr 2016MP04-18 LONGITUDINAL REGRET AND HEALTH-RELATED QUALITY OF LIFE FOLLOWING TREATMENT FOR LOW- INTERMEDIATE-RISK PROSTATE CANCER Lauren Hurwitz, Jennifer Cullen, Daniel Kim, Sally Elsamanoudi, Jane Hudak, Maryellen Colston, Judith Travis, Huai-Ching Kuo, David McLeod, and Inger Rosner HurwitzLauren Hurwitz More articles by this author , CullenJennifer Cullen KimDaniel Kim ElsamanoudiSally Elsamanoudi...
You have accessJournal of UrologyProstate Cancer: Staging I1 Apr 2016PD42-10 NUCLEAR GRADE PREDICTS PROSTATE CANCER OUTCOMES AMONG RADICAL PROSTATECTOMY PATIENTS Daniel Kim, Lauren Hurwitz, Huai-Ching Kuo, Jennifer Cullen, Sally Elsamanoudi, Yongmei Chen, Inger Rosner, David McLeod, and Isabel Sesterhenn KimDaniel Kim More articles by this author , HurwitzLauren Hurwitz KuoHuai-Ching Kuo CullenJennifer Cullen ElsamanoudiSally Elsamanoudi ChenYongmei Chen RosnerInger Rosner McLeodDavid McLeod...
48 Background: Racial disparities in prostate cancer (PCa) incidence, health-related quality of life (HRQoL), treatment outcomes, and decisional regret have been reported. This study evaluated decision-making African American (AA) Caucasian (CA) patients with localized PCa to better understand HRQoL domains associated post-treatment regret. Methods: is a prospective cohort evaluating low- intermediate-risk racially diverse, equal access health-care setting who enrolled multidisciplinary...
Abstract Background: Immunobiological factors may, in part, contribute to racial disparities prostate cancer (PCa), the second leading cause of cancer-related death for US men. African American (AA) men face a greater risk developing PCa and having poorer outcome this disease, compared Caucasian (CA) The goal study is identify immune-specific differences influencing health disparity as well progression. Methods: Ex vivo tumor biopsies were obtained following radical prostatectomy (RP) from...
<p>Supplementary Figure S11 shows BCR-free and Metastasis-free survival for cell types dichotomized by median cutoffs.</p>