A5011099982- Chronic Obstructive Pulmonary Disease (COPD) Research
- Exercise and Physiological Responses
- Elasticity and Material Modeling
- Cardiovascular Health and Disease Prevention
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion Channels and Receptors
- Transcranial Magnetic Stimulation Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Electromagnetic Fields and Biological Effects
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Neurological Disease Mechanisms and Treatments
- Muscle metabolism and nutrition
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nitric Oxide and Endothelin Effects
- Photoreceptor and optogenetics research
- Aortic aneurysm repair treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
Maastricht University
2020-2025
Background The development of vascular cognitive impairment (VCI) and heart failure with preserved ejection fraction (HFpEF) are strongly associated comorbidities such as obesity, diabetes, hypertension, aging. Microvascular dysfunction may be key a pathological step in the during HFpEF. Hence, we aimed to evaluate cerebrovascular phenotype ZSF1 rats identify molecular processes central VCI Methods Male Lean Obese underwent blood pressure glucose measurements, echocardiography series...
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory characterized by small airway remodeling and alveolar emphysema due to environmental stresses such as cigarette smoking (CS). Oxidative stress commonly implicated in COPD pathology, but recent findings suggest that one oxidant-producing NADPH oxidase homolog, dual 1 (DUOX1), downregulated the airways of patients with COPD. We evaluated lung tissue sections from for epithelial DUOX1 protein expression, association measures...
Extremely low frequency electromagnetic stimulation (ELF-EMS) has been considered as a neuroprotective therapy for ischemic stroke based on its capacity to induce nitric oxide (NO) signaling. Here, we examined whether ELF-EMS reduces volume by stimulating cerebral collateral perfusion. Moreover, the pathway responsible ELF-EMS-induced NO production was investigated. diminished infarct growth following experimental in collateral-rich C57BL/6 mice, but not collateral-scarce BALB/c suggesting...
Biological tissues decay over time after harvesting, which alters their biomechanical properties. This poses logistical challenges for studies investigating passive arterial biomechanics as need to be characterized shortly excision. Freezing and cryopreservation methods can help alleviate the testing of fresh tissue in human ex vivo studies. However, these tend eliminate or reduce cell functionality affect biomechanics. Furthermore, impact on dynamic remains unknown despite viscoelastic...
Muscle atrophy is an extrapulmonary complication of acute exacerbations (AE) in chronic obstructive pulmonary disease (COPD). The endogenous production and therapeutic application glucocorticoids (GCs) have been implicated as drivers muscle loss AE-COPD. enzyme 11 β-hydroxysteroid dehydrogenase 1 (11β-HSD1) activates GCs contributes toward GC-induced wasting. To explore the potential 11βHSD1 inhibition to prevent wasting here, objective this study was ascertain contribution GC activation...
ABSTRACT Most studies investigating arterial stiffening use animal rather than human arteries. This is because tissue becomes available in small amounts and at irregular times, which complicates planning of experimental work. Suitable preservation methods for delayed biomechanical testing prevents the need fresh alleviates some logistical challenges ex vivo studies. Therefore, present study aimed to investigate whether existing method flash freezing subsequent cryostorage provides suitable...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)