A5075332925- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Exercise and Physiological Responses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Blood disorders and treatments
- Occupational exposure and asthma
- Asthma and respiratory diseases
- Cell Adhesion Molecules Research
- S100 Proteins and Annexins
- Muscle metabolism and nutrition
- Immune cells in cancer
BioTelemetry (United States)
2024
Maastricht University
2023
Eosinophils are a subset of granulocytes that protect the host against fungal and parasitic infection through secretion their granular contents. In response to specific stimuli, eosinophils also undergo type lytic cell death, referred as eosinophil extracellular trap (EET)-associated death (EETosis), where histone citrullination facilitates chromatin decondensation, rupture release pro-inflammatory, decondensed into environment EETs. this study, we show abundant presence citrullinated...
Neutrophil extracellular traps (NETs) contribute to the pathophysiology of multiple inflammatory and autoimmune diseases. Targeting NETosis pathway has demonstrated significant therapeutic potency in various disease models. Here, we describe a first-in-class monoclonal antibody (CIT-013) with high affinity for citrullinated histones H2A H4, which inhibits reduces tissue NET burden
Neutrophils play an important role in innate immune defense by using several strategies, including the release of neutrophil extracellular traps (NETs) a process referred to as NETosis. However, past two decades, it has become clear that accumulation NETs tissues contributes pathophysiology multiple inflammatory and autoimmune diseases. Therefore, interest development NETosis antagonists risen. Variable non-standardized methods detect analyze were developed concomitantly, each with its own...
Muscle atrophy is an extrapulmonary complication of acute exacerbations (AE) in chronic obstructive pulmonary disease (COPD). The endogenous production and therapeutic application glucocorticoids (GCs) have been implicated as drivers muscle loss AE-COPD. enzyme 11 β-hydroxysteroid dehydrogenase 1 (11β-HSD1) activates GCs contributes toward GC-induced wasting. To explore the potential 11βHSD1 inhibition to prevent wasting here, objective this study was ascertain contribution GC activation...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)