A5008359791- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- SARS-CoV-2 detection and testing
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Animal Virus Infections Studies
- Systemic Lupus Erythematosus Research
- Biosensors and Analytical Detection
- Inflammatory Bowel Disease
- HIV/AIDS Research and Interventions
- Polyamine Metabolism and Applications
- Amino Acid Enzymes and Metabolism
- Extracellular vesicles in disease
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Acoustic Wave Resonator Technologies
- Pharmaceutical studies and practices
- Adhesion, Friction, and Surface Interactions
- Coronary Interventions and Diagnostics
- Protein purification and stability
- Circular RNAs in diseases
Abbott Fund
2002-2025
Abbott (United States)
2020-2024
Northern Illinois University
1996
Abstract Aims The association between microRNAs (miRNAs) and established cardiac biomarkers is largely unknown. We aimed to measure the plasma miRNAs N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), troponin I, soluble urokinase‐type plasminogen activator receptor (suPAR), galectin‐3 with structure function clinical outcomes. Methods results quantified 32 using FirePlex miRNA assay measured in 139 individuals symptomatic heart failure (HF). used principal component (PC) analysis linear...
Evidence suggests patients with inflammatory bowel disease [IBD] receiving TNF antagonists have attenuated response to vaccination against COVID-19. We sought determine the impact of IBD and various medications for treatment on antibody responses Patients [n = 270] healthy controls [HC, n 116] were recruited prospectively, quantitative assessed following COVID-19 vaccination. The vaccine rates was investigated. Of HC, 100% seroconverted complete two doses; 2% failed seroconvert. Median...
ABSTRACT Systemic inflammation is associated with COVID-19 mortality rates, but the impact of on neutralizing antibodies to severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and outcomes poorly understood. This study aimed determine association between antibody responses, inflammation, clinical in hospitalized patients COVID-19. Two hundred eight presenting ED symptomatic SARS-CoV-2 were included. Neutralization was assessed using architect angiotensin-converting enzyme-2...
ABSTRACT World Health Organization recommends anti‐HCV antibody testing for primary screening to be followed by HCV‐RNA. However, current serological assays are prone false‐positive results. We ascertained the ability of newly developed Abbott Alinity‐i Next assay (Research‐Use‐Only) resolve false‐positives and profiled its performance edges. Samples ( n = 2186) received from January June 2024 were subjected using Architect (Abbott), LIAISON XL MUREX HCV assays. categorized based on signal...
ABSTRACT In this study, we evaluated the performance of two prototype human immunodeficiency virus (HIV) antigen-antibody (Ag-Ab) combination assays, one from Abbott Laboratories (AxSYM HIV Ag-Ab) and other bioMerieux (VIDAS Duo Ultra), versus five assays commercially available in Europe. The were Enzygnost Integral, Genscreen Plus Ag-Ab, Murex Ag-Ab Combination, VIDAS Duo, Vironostika Uniform II Ag-Ab. All for ability to detect p24 antigen HIV-1 groups M O, antibody-positive plasma samples...
ABSTRACT A collaborative multicenter study was conducted to evaluate the sensitivity, specificity, and precision of a three-step, fully automated, qualitative microparticle-based enzyme-linked immunoassay (AxSYM HIV Ag/Ab Combo; Abbott Laboratories), designed simultaneously detect (i) antibodies against human immunodeficiency virus type 1 (HIV-1) and/or 2 (HIV-2) (ii) p24 antigen. significant reduction in seroconversion window achieved by combining detection antigen into single assay format....
Abstract Background Longitudinal serology studies can assist in analyzing the kinetics of antibodies to SARS-CoV-2, helping inform public health decision making. Our study aims characterize circulating antibody trends over 18 months vaccinated participants with and without evidence COVID-19 infection. Methods A cohort care workers employed at Boston Medical Center was followed collect serum samples survey data 6 time points from July 2020 through December 2021 (N = 527). History SARS-CoV-2...
The Abbott Alinity family of chemistry and immunoassay systems recently launched with early adopters contributing imprecision bias data, which was consolidated to assess the performance assays across multiple sites using Sigma metric. Multi-site metrics were determined for 3 ion-selective electrodes, 12 photometric assays, immunoassays 11 independent laboratory in 9 countries. Total allowable error (TEa) goals followed a previously defined hierarchy that used CLIA as primary goal. Bias...
Patients with inflammatory bowel disease [IBD] have an attenuated response to initial COVID-19 vaccination. We sought characterize the impact of IBD and its treatment on responses after third vaccine against SARS-CoV-2.This was a prospective multicentre observational study patients [n = 202] healthy controls [HC, n 92]. Serological vaccination assessed by quantification anti-spike protein [SP] immunoglobulin [Ig]G levels [anti-SPIgG] in vitro neutralization binding angiotensin-converting...
DH23b cells, a variant of the HTC line selected for their resistance to difluoromethylornithine, exhibit defective feedback regulation ornithine decarboxylase (ODC) stability and polyamine transport, accumulate ODC protein > 1000 times normal concentrations. The components system have been examined in an attempt understand these unusual responses. Southern-blot analysis revealed amplification (approx. 10-fold) DNA sequence without any concomitant increase antizyme. Moreover, amplified...
Abstract Background Viral diversity presents an ongoing challenge for diagnostic tests, which need to accurately detect all circulating variants. The Abbott Global Surveillance program monitors severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants and their impact on test performance. Objectives To evaluate the capacity of molecular, antigen, serologic assays SARS-CoV-2 B.1.1.7, B.1.351 P.1 Study design Virus variant culture stock dilutions (B.1.1.7, BEI NR-54011; B.1.351,...
SARS-CoV-2 mRNA vaccines have been critical to curbing pandemic COVID-19; however, a major shortcoming has the inability assess levels of protection after vaccination. This study assessed serologic status breakthrough infections in vaccinated patients at Veterans Administration medical center from June through December 2021 during delta variant wave. Breakthrough occurred mostly beyond 150 days two-dose vaccination with mean 239 days. Anti-SARS-CoV-2 spike (S) IgG were low 0 2 postsymptoms...
Abstract Background Patients with inflammatory bowel disease (IBD) have attenuated responses to current vaccinations. There is a limited body of evidence suggesting patients IBD receiving TNF antagonists an response vaccination against COVID-19. We sought determine the impact and various medications for treatment on antibody Methods (n=270) healthy controls (HC, n=116) were recruited prospectively quantitative assessed following 1st 2nd doses COVID-19 vaccination. The vaccine rates was...
Abstract Background Numerous studies have demonstrated an association between systemic inflammation and mortality in patients with COVID-19. However, it is unclear how neutralizing antibody to severe acute respiratory syndrome related coronavirus 2 (SARS-CoV-2) associates outcomes. Further, impacts production relatively poorly understood. The aim of this study was determine the response SARS-CoV-2, inflammatory markers, clinical outcomes a cohort hospitalized without prior...
ABSTRACT The prevalence of hepatitis C virus (HCV) infection in the United States has increased over past decade despite development effective direct-acting antiviral treatments. To meet World Health Organization’s (WHO) goal eliminating HCV by 2030, transmission events must be reduced. Currently, screening relies on detection antibodies, with nucleic acid amplification testing (NAAT) used to confirm viremia and monitor changes viral load. However, seroconversion window for antibodies is...
Abstract Background Serological testing for SARS-CoV-2 is integral understanding prevalence of disease, tracking infections, confirming humoral response to vaccines, and determining timing efficacy boosters. The study objective was compare the specificity serology assays in emergency department populations across United States 2019 (pre-pandemic) early 2020, incorporating an automated confirmatory assay. Methods Patient specimens (n = 1954) were from 4 regions States: New York, NY;...
Abstract Introduction Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is diagnosed molecular-based detection of SARS-CoV-2 RNA. Serologic testing detects antibodies specific to and IgM specifically may serve as an adjunct test PCR early in disease. We evaluated the Abbott anti-SARS-CoV-2 IgG assays along with DiaSorin Roche Total. Methods Specimens from 175 PCR-positive patients 107 control specimens were analyzed using IgG, Total...