A5048583850- Supramolecular Self-Assembly in Materials
- Chemical Synthesis and Analysis
- RNA Interference and Gene Delivery
- Treatment of Major Depression
- Tryptophan and brain disorders
- Advanced biosensing and bioanalysis techniques
- Polydiacetylene-based materials and applications
- Protein Tyrosine Phosphatases
- Diet and metabolism studies
- Alcoholism and Thiamine Deficiency
- Supramolecular Chemistry and Complexes
- Redox biology and oxidative stress
- Digestive system and related health
- Phytoestrogen effects and research
- Nutrition, Genetics, and Disease
- Silk-based biomaterials and applications
Lake Erie College of Osteopathic Medicine
2024
Brandeis University
2015-2018
Kyoto Prefectural University
2000
Selective inhibition of cancer cells remains a challenge in chemotherapy. Here we report the molecular and cellular validation enzyme-instructed self-assembly (EISA) as multiple step process for selectively killing that overexpress alkaline phosphatases (ALPs). We design synthesize two kinds d-tetrapeptide containing one or phosphotyrosine residues with N-terminal capped by naphthyl group. Upon enzymatic dephosphorylation, these d-tetrapeptides turn into self-assembling molecules to form...
Due to their biostability, d-peptides are emerging as an important molecular platform for biomedical applications. Being proteolytically resistant, lack interactions with endogenous transporters and hardly enter cells. Here we show that taurine, a natural amino acid, drastically boosts the cellular uptake of small in mammalian cells by >10-fold, from 118 μM (without conjugating taurine) >1.6 mM (after taurine). The large amount ester conjugate taurine d-peptide allows intracellular esterase...
Most of the peptides used for promoting cellular uptake bear positive charges. In our previous study, we reported an example taurine (bearing negative charges in physiological conditions) D-peptides. Taurine, conjugated to a small D-peptide via ester bond, promotes this D-peptide. Particularly, intracellular carboxylesterase (CES) instructs self-assemble and form nanofibers, which largely disfavors efflux further enhances accumulation D-peptide, as supported by that addition CES inhibitors...
In order to obtain information on the preventive effects of various food pro-teins against colonic cancer, six groups azoxymethane-initiated mature Fischer rats (n=10) were fed respective diets different in protein sources such as bovine milk casein (ca-sein), high-molecular-weight fraction from protolytic digest soy isolate (soybean HMF), hen's yolk defatted (yolk protein), wheat gluten and codfish meat, which had been supplemented with sodium deoxycholate (hereinafter, DCA) a cancer...
The aim of this short narrative review was to evaluate the existing literature regarding clinical use ketamine among individuals with dementia, especially those behavioral disturbances. PubMed, Cochrane, and Ovid (Embase, APA PsycINFO, MEDLINE) databases were searched for abstracts using search terms “ketamine” AND “dementia.” Only articles describing in dementia included. Articles that did not include ketamine, published a non-English language, primarily described animal studies, or reviews...
An immunoreceptor tyrosine-based inhibitory motif (ITIM), LYYYYL, as well its enantiomeric or retro-inverso peptide, self-assembles in water upon enzymatic dephosphorylation, thus illustrating a new approach to design bioinspired soft materials from an important pool of functional peptides.