A5080686380- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Nuclear Receptors and Signaling
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Neurological Disease Mechanisms and Treatments
- RNA regulation and disease
National Institute for Viral Disease Control and Prevention
2021-2025
Chinese Center For Disease Control and Prevention
2021
ABSTRACT Mucosal immunity is essential for preventing viral infections through the mucosal route. The emerging SARS‐CoV‐2 variants have posed additional hurdles to efficiency of existing vaccines. rapid development novel vaccines that generate broad and systemic could be most effective strategy address this issue. In study, we developed a recombinant replication‐deficient type‐5 adenoviral vaccine with built‐in double‐strand RNA adjuvant expresses Omicron BA.1 spike (S) antigen (hereinafter...
Group A rotaviruses (RVAs) are the most common etiological agents of severe acute diarrhea among children under 5 years old worldwide. At present, two live-attenuated RVA vaccines, LLR (G10P[15]) and RotaTeq (G1-G4, G6 P[8], P[5]), have been introduced to mainland China. Although vaccines can provide homotypic partially heterotypic protection against several strains, it is necessary explore genetic antigenic variations between circulating RVAs vaccine strains. In this study, we sequenced...
A novel Norovirus (NoV) was identified by viral metagenomic analysis in fox fecal samples from the Xinjiang Uygur Autonomous Region of China. The virus exhibited typical genomic characteristics NoVs. It closely related to canine NoV GVII strains with 86.0–86.2% and 91.9% amino acid identities capsid protein VP1 RNA-dependent RNA polymerase (RdRp), respectively. clustered phylogenetically two strains, it distant other According new classification criteria NoVs, belongs same genotype as GVII,...
Rotavirus A (RVA) G3P[8] is sporadically detected in China, although G9P[8] predominates. To evaluate their genetic composition at the whole-genome level, 24 RVA strains isolated from children under five years were sequenced and characterized. The genotyped as G3-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1, indicating Wa-like genotype constellation. maximum clade credibility (MCC) tree for VP7 indicated that G3 had an estimated mean evolutionary rate of 7.279 × 10−4 substitutions/site/year; thus, 3–5...
Abstract Two samples positive for the same strain (2103CP) of human astrovirus (HAstV) were identified during an acute gastroenteritis outbreak in Beijing, China. A full genomic analysis showed that both samples, open reading frame 1a (ORF1a) clustered with HAstV-1, whereas ORF1b and ORF2 HAstV-5. The recombination site was detected upstream region where ORF1a overlapped. Recombinant HAstV-5 strains reported previously China 2013 2021. Our results indicate need continuous surveillance...