A5053846203- School Health and Nursing Education
- CAR-T cell therapy research
- Carcinogens and Genotoxicity Assessment
- Occupational and environmental lung diseases
- Smoking Behavior and Cessation
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- CRISPR and Genetic Engineering
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Obesity, Physical Activity, Diet
- T-cell and Retrovirus Studies
- Colorectal Cancer Screening and Detection
- Air Quality and Health Impacts
- Insurance, Mortality, Demography, Risk Management
- Diverticular Disease and Complications
Q Therapeutics (United States)
2024
Cancer Care Ontario
2012
Wayne State University
2005
Imperial Oil (Canada)
2003
ExxonMobil (United States)
1996
Aims: To assess mortality and cancer morbidity in Canadian petroleum workers explore exposure-response relations for specific agents. Methods: A total of 25 292 employees hired between 1964 1994 were linked to the tumour registry national database. Exposure-response trends assessed hydrocarbon solvents/fuels, lubricants, coke/spent catalyst, hydrogen sulphide (H 2 S). Results: External comparison analyses (mortality incidence) showed deficits all causes malignant neoplasms combined...
To evaluate the relation between mortality from lymphohaematopoietic cancer and long term, low level exposures to benzene among male petroleum distribution workers.This nested case control study identified all fatal cases of a previously studied cohort. Of 29 cases, 14 had leukaemia, seven multiple myeloma, eight non-Hodgkin's lymphoma. A four one matching ratio was used select stratified sample controls same cohort, controlling for year birth time at risk. Industrial hygienists estimated...
Cell therapies such as tumor-infiltrating lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, improvement response rates and durability responses nevertheless sought. To identify targets capable enhancing antitumor activity T cell therapies, large-scale vitro vivo clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 screens were performed, SOCS1 gene identified a top cell-enhancing target. In murine CD8+ cell-therapy...
<h3>Background</h3> The use of CRISPR/Cas9-gene-editing to enhance the anti-tumor activity T cell therapies is a promising approach in treatment patients with solid tumors. We previously reported utility vivo pair-wise CRISPR/Cas9 screens identify best target combinations cells able function, SOCS1 and Regnase-1 identified as top combination. In these studies, we further explore mechanisms by which dual-inactivation enhances activity. <h3>Methods</h3> efficacy transferred SOCS1/Regnase-1...