A5012019232- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Gaze Tracking and Assistive Technology
- Muscle activation and electromyography studies
- Neurological disorders and treatments
- Sleep and Wakefulness Research
- Amyotrophic Lateral Sclerosis Research
- Neural dynamics and brain function
- Sleep and related disorders
- Machine Learning in Healthcare
- Genomics and Rare Diseases
- Biomedical Ethics and Regulation
- Olfactory and Sensory Function Studies
- Stability and Control of Uncertain Systems
- Neural and Behavioral Psychology Studies
- Tactile and Sensory Interactions
- Advanced Sensor and Energy Harvesting Materials
- Restless Legs Syndrome Research
- Circadian rhythm and melatonin
- Parkinson's Disease Mechanisms and Treatments
- Advanced Memory and Neural Computing
- Stroke Rehabilitation and Recovery
- Non-Invasive Vital Sign Monitoring
Wyss Center for Bio and Neuroengineering
2020-2022
University of Tübingen
2018-2021
University of Padua
2016-2017
Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means communication. While others have evaluated in people remaining muscle control, to the best our knowledge, it is not known whether neural-based remains possible a completely locked-in state. Here, we implanted two 64 microelectrode arrays supplementary primary cortex patient state ALS. The modulated...
Abstract Patients in the transition from locked-in (i.e., a state of almost complete paralysis with voluntary eye movement control, blinks or twitches face muscles, and preserved consciousness) to total including eye-muscles loss gaze-fixation, combined are left without any means communication. An auditory communication system based on electrooculogram (EOG) was developed enable such patients communicate. Four amyotrophic lateral sclerosis completely state, ALSFRS-R score 0, unable use...
The dataset presented here contains recordings of electroencephalogram (EEG) and electrooculogram (EOG) from four advanced locked-in state (LIS) patients suffering ALS (amyotrophic lateral sclerosis). These could no longer use commercial eye-trackers, but they still move their eyes used the remnant oculomotor activity to select letters form words sentences using a novel auditory communication system. Data were recorded during variable range visits (from 2 10), each visit comprised 3.22 ±...
Electrooculography (EOG) signals have been widely used in Human-Computer Interfaces (HCI). The HCI systems proposed the literature make use of self-designed or closed environments, which restrict number potential users and applications. Here, we present a system for classifying four directions eye movements employing EOG signals. is based on open source ecosystems, Raspberry Pi single-board computer, OpenBCI biosignal acquisition device, an open-source python library. designed provides...
Persons in the completely locked-in state (CLIS) suffering from amyotrophic lateral sclerosis (ALS) are deprived of many zeitgebers circadian rhythm: While cognitively intact, they paralyzed, eyes mostly closed, with artificial ventilation and nutrition, social communication extremely restricted or absent. Polysomnographic recordings eight patients CLIS, however, revealed presence regular episodes deep sleep during night time all patients. It was also possible to distinguish an alpha-like a...
Abstract Persons with their eye closed and without any means of communication is said to be in a completely locked-in state (CLIS) while when they could still open eyes actively or passively have some are (LIS). Two patients CLIS communication, one patient the transition from LIS who Amyotrophic Lateral Sclerosis were followed at regular interval for more than 1 year. During each visit, resting-state EEG was recorded before brain–computer interface (BCI) based sessions. The analyzed...
Knowing the force exerted by a human operator while he/she is performing specific task important in many different field. For instance, limiting or optimizing effort sport activities allows for development of training patterns athletes, knowing made worker when lifts weight from point view safety. The effective not only related to net force/torque generated, but also generated each muscle. This aspect most crucial be evaluated, as non properly designed/handled exercise/task can lead an...
Several technological solutions have ben recently proposed for fingers rehabilitation in patients who were affected by a stroke, particular those cannot generate the finger force but with preserved sEMG signals. In fact, very promising approach uses robot system controlled through However, this has two main problems: 1) placement of electrodes is made manually and could bring to non-optimal detection signals; 2) cost treatments high, mainly due usage single-use, dispodsable electrodes. Our...
Brain computer interfaces (BCIs) enables people with motor impairments to communicate using their brain signals by selecting letters and words from a screen. However, these spellers do not work for in complete locked-in state (CLIS). For patients, near infrared spectroscopy-based BCI has been developed, allowing them reply “yes”/”no” questions classification accuracy of 70%. Because the non-optimal accuracy, usual character-based speller or cannot be used. In this paper, novel spelling...
Abstract Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means communication. While others have evaluated in people remaining muscle control, to the best our knowledge, it is not known whether neural-based remains possible a completely locked-in state (CLIS). With consent approval participant, family, legal authority for this study, two 64 microelectrode...
Abstract To develop a more reliable brain–computer interface (BCI) for patients in the completely locked-in state (CLIS), here we propose Pavlovian conditioning paradigm using galvanic vestibular stimulation (GVS), which can induce strong sensation of equilibrium distortion individuals. We hypothesized that associating two different sensations caused by two-directional GVS with thoughts “yes” and “no” individuals would enable us to emphasize differences brain activity associated yes no hence...