A5015818377- Salivary Gland Disorders and Functions
- Hedgehog Signaling Pathway Studies
- Head and Neck Cancer Studies
- Neonatal Respiratory Health Research
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Salivary Gland Tumors Diagnosis and Treatment
University at Albany, State University of New York
2022-2023
Albany State University
2023
Albany Medical Center Hospital
2023
Fibrosis results from excess extracellular matrix accumulation, which alters normal tissue architecture and impedes function. In the salivary gland, fibrosis can be induced by irradiation treatment for cancer therapy, Sjögren's Disease, other causes; however, it is unclear stromal cells signals participate in injury responses disease progression. As hedgehog signaling has been implicated of gland organs, we examined contributions effector, Gli1, to fibrotic glands. To experimentally induce a...
Abstract Fibrosis results from excess extracellular matrix accumulation, which alters normal tissue architecture and impedes function. In the salivary gland, fibrosis can be induced by irradiation treatment for cancer therapy, Sjögren’s Disease, other causes; however, it is unclear stromal cells signals participate in injury responses disease progression. As hedgehog signaling has been implicated of gland organs, we examined contributions effector, Gli1, to fibrotic glands. To experimentally...
Fibrosis results from excess extracellular matrix deposition, which alters normal tissue architecture and impedes function. Salivary gland fibrosis can be caused by irradiation therapy, as a treatment for head neck cancer, well the autoimmune disease Sjögren's Syndrome. The mechanisms that contribute to are complex poorly understood; however, defining cell types signaling pathways involved could reveal potential therapeutic targets. Stromal subpopulations have been shown fibrosis....