A5079711190- Salivary Gland Disorders and Functions
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Fibroblast Growth Factor Research
- Hedgehog Signaling Pathway Studies
Albany State University
2023-2025
University at Albany, State University of New York
2023-2025
Fibrosis results from excess extracellular matrix accumulation, which alters normal tissue architecture and impedes function. In the salivary gland, fibrosis can be induced by irradiation treatment for cancer therapy, Sjögren's Disease, other causes; however, it is unclear stromal cells signals participate in injury responses disease progression. As hedgehog signaling has been implicated of gland organs, we examined contributions effector, Gli1, to fibrotic glands. To experimentally induce a...
Extracellular matrix remodeling is a natural response to injury but, excessive extracellular accumulation, or fibrosis, causative factor in hundreds of diseases that limit organ function, regenerative responses, and can interfere with therapies. Fibrosis closely related inflammation, both which occur the salivary glands patients treated radiation for head neck cancers suffering from autoimmune conditions, such as Sjögren's Disease. Despite known involvement fibrosis disease inhibitory...
Abstract Fibrosis results from excess extracellular matrix accumulation, which alters normal tissue architecture and impedes function. In the salivary gland, fibrosis can be induced by irradiation treatment for cancer therapy, Sjögren’s Disease, other causes; however, it is unclear stromal cells signals participate in injury responses disease progression. As hedgehog signaling has been implicated of gland organs, we examined contributions effector, Gli1, to fibrotic glands. To experimentally...