A5009833611- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Neurobiology and Insect Physiology Research
- Computational Drug Discovery Methods
Université Côte d'Azur
2023-2024
Institut de Chimie de Nice
2021-2024
Centre National de la Recherche Scientifique
2023
Abstract Mammalian sense of smell is triggered by interaction between odorant molecules and a class proteins, called olfactory receptors (ORs). These receptors, expressed at the surface sensory neurons, encode myriad distinct odors via sophisticated activation pattern. However, determining molecular recognition spectrum ORs remains major challenge. The Molecule to Olfactory Receptor database (M2OR, https://m2or.chemsensim.fr/) provides curated data that allows an easy exploration current...
Abstract Olfactory perception begins when odorous substances interact with specialized receptors located on the surface of dedicated sensory neurons. The recognition smells depends a complex mechanism involving combination interactions between an odorant and set (ORs), where molecules are recognized according to combinatorial activation code ORs. Although these have been studied for decades, rules governing this ligand remain poorly understood, complete is only known handful odorants. We...