A5108893318- Orthopedic Infections and Treatments
- Lipid Membrane Structure and Behavior
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Mycobacterium research and diagnosis
- RNA Interference and Gene Delivery
- Bacterial Identification and Susceptibility Testing
- Immune Response and Inflammation
- Infective Endocarditis Diagnosis and Management
Central South University
2024
Shandong University
2023-2024
Second Xiangya Hospital of Central South University
2024
Shandong Provincial Hospital
2023
Shandong First Medical University
2023
Sepsis, which is the most severe clinical manifestation of acute infection and has a mortality rate higher than that cancer, represents significant global public health burden. Persistent methicillin-resistant
Tracking and eradicating Staphylococcus aureus in the periprosthetic microenvironment are critical for preventing joint infection (PJI), yet effective strategies remain elusive. Here, we report an implant nanoparticle coating that locoregionally yields bactericidal super chimeric antigen receptor macrophages (CAR-MΦs) to prevent PJI. We demonstrate plasmid-laden from can introduce S. aureus-targeted CAR genes caspase-11 short hairpin RNA (CASP11 shRNA) into macrophage nuclei generate CAR-MΦs...
Metagenomic next-generation sequencing (mNGS) has been widely reported to identify pathogens in infectious diseases (IDs). In this work, we intended investigate the diagnostic value and clinical acceptance of paired-samples mNGS as compared culture method.