A5091359524- Neuroinflammation and Neurodegeneration Mechanisms
- Galectins and Cancer Biology
- Research on Leishmaniasis Studies
- Pediatric health and respiratory diseases
- Dermatological and Skeletal Disorders
- Hair Growth and Disorders
- Retinal Diseases and Treatments
- Alzheimer's disease research and treatments
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Glycosylation and Glycoproteins Research
- Complement system in diseases
- Inflammatory Myopathies and Dermatomyositis
University Hospital Bonn
2024
University of Bonn
2024
is missing (Short communication).
Abstract Sialylation plays an important role in self‐recognition, as well keeping the complement and innate immune systems check. It is unclear whether reduced sialylation seen during aging mice heterozygous for null mutant of UDP‐N‐acetylglucosamine 2‐epimerase/N‐acetylmannosamine kinase (Gne+/−), essential enzyme sialic acid biosynthesis, contributes to retinal inflammation degeneration. We found a reduction polysialic trisialic expression several layers Gne+/− at 9 months age compared...
Brain aging is a chronic process linked to inflammation, microglial activation, and oxidative damage, which can ultimately lead neuronal loss. Sialic acid-binding immunoglobulin-like lectin-11 (SIGLEC-11) human lineage-specific cell surface receptor that recognizes α -2-8-linked oligo−/polysialylated glycomolecules with inhibitory effects on the inflammatory pathways. Recently, SIGLEC11 gene locus was prioritized as top tier potential causality Alzheimer’s disease, although its role in...