A5027736041- Diphtheria, Corynebacterium, and Tetanus
- Biomedical Text Mining and Ontologies
- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- Bioinformatics and Genomic Networks
- Genetics and Neurodevelopmental Disorders
- Cancer Immunotherapy and Biomarkers
- Mycobacterium research and diagnosis
- Genetics, Bioinformatics, and Biomedical Research
- CAR-T cell therapy research
- Computational Drug Discovery Methods
- Toxin Mechanisms and Immunotoxins
- Microtubule and mitosis dynamics
- Mechanisms of cancer metastasis
- Immune Cell Function and Interaction
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2025
Universitätsklinikum Erlangen
2023-2025
University of Naples Federico II
2017
Ceinge Biotecnologie Avanzate (Italy)
2017
PRUNE is a member of the DHH (Asp-His-His) phosphoesterase protein superfamily molecules important for cell motility, and implicated in cancer progression. Here we investigated multiple families from Oman, India, Iran Italy with individuals affected by new autosomal recessive neurodevelopmental degenerative disorder which cardinal features include primary microcephaly profound global developmental delay. Our genetic studies identified biallelic mutations PRUNE1 as responsible. functional...
The accelerating growth of scientific literature overwhelms our capacity to manually distil complex phenomena like molecular networks linked diseases. Moreover, biases in biomedical research and database annotation limit interpretation facts generation hypotheses. ENQUIRE (Expanding Networks by Querying Unexpectedly Inter-Related Entities) offers a time- resource-efficient alternative manual curation mining. reconstructs expands co-occurrence genes ontologies from user-selected input corpora...
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light the simultaneous intracellular adaptation bacteria changes in proteome phagocytes response internalization C. . Quantitative analyses were carried out at different time points an infection assay data analyzed by bioinformatic approaches. Several proteins, which not observed or connected pathogenicity before,...
Abstract The genus Corynebacterium includes species of biotechnological, medical and veterinary importance. An atypical C. ulcerans strain, W25, was recently isolated from a case necrotizing lymphadenitis in wild boar. In this study, we have analysed the genome sequence strain compared phenotypic virulence properties with other corynebacterial pathogens. Phylogenomic analyses revealed that W25 belongs to novel along PO100/5 KL1196. latter strains were pig roe deer, respectively; hence,...
Melanoma is a metastatic, drug-refractory cancer with the ability to evade immunosurveillance. Cancer immune evasion involves interaction between tumor intrinsic properties and microenvironment. The transcription factor E2F1 key driver of evolution metastasis. To explore E2F1's role in regulation presence aggressive melanoma cells, we established coculture system utilized transcriptome cytokine arrays combined bioinformatics structural modeling. We identified an E2F1-dependent gene...
Host-pathogen interactions are often studied in vitro using primary or immortal cell lines. This set-up avoids ethical problems of animal testing and has the additional advantage lower costs. However, influence culture media on bacterial growth metabolism is not considered investigated most cases. To address this question proteome adaptation Corynebacterium diphtheriae strain ISS3319 were study. Bacteria cultured standard medium, fetal calf serum. Mass spectrometric analyses label-free...
ABSTRACT The accelerating growth of scientific literature overwhelms our capacity to manually distil complex phenomena like molecular networks linked diseases. Moreover, biases in biomedical research and database annotation limit interpretation facts generation hypotheses. ENQUIRE (Expanding Networks by Querying Unexpectedly Inter-Related Entities) offers a time- resource-efficient alternative manual curation mining. reconstructs expands co-occurrence genes ontologies from user-selected...