A5031339370- Neurobiology and Insect Physiology Research
- Animal Behavior and Reproduction
- Hearing, Cochlea, Tinnitus, Genetics
- Plant and Biological Electrophysiology Studies
- Insect and Arachnid Ecology and Behavior
- Planarian Biology and Electrostimulation
- Hearing Loss and Rehabilitation
- Plant Molecular Biology Research
- Noise Effects and Management
University of Leicester
2022-2024
One leading hypothesis for why we lose our hearing as age is a decrease in ear metabolism. However, direct measurements of metabolism across lifespan any auditory system are lacking. Even if does with age, question remains: metabolic cause age-related decline or simply correlative? We use an insect, the desert locust
After overexposure to loud music, we experience a decrease in our ability hear (robustness), which usually recovers (resilience). Here, exploited the amenable auditory system of desert locust, Schistocerca gregaria, measure how robustness and resilience depend on age. We found that gene expression changes are dominated by age as opposed noise exposure. measured sound-evoked nerve activity for young aged locusts directly, after 24 hours 48 both recovered their function over hours. also...
Abstract Age-related auditory decline manifests across the animal kingdom, from humans and mice to zebrafish insects. Sex differences in are established for humans, but there is now evidence even zebrafish. Here, we found sex an insect, Desert Locust investigated its biological basis. We profiled gene expression a dedicated organ, Müller’s organ understand genetic underpinning of measured sound-evoked transduction currents electrophysiological properties neurons quantify decline. analysed...
Abstract Insect cuticle is an evolutionary-malleable exoskeleton that has specialised for various functions. Insects detect the pressure component of sound bear sound-capturing tympani evolved from cuticular thinning. Whilst outer layer insect composed non-living chitin, its mechanical properties change during development and aging. Here, we measured displacements tympanum desert Locust, Schistocerca gregaria , to understand biomechanical changes as a function age noise-exposure. We found...
How far we fall and the speed at which get back up represent two aspects of perseverance: robustness resilience. One sense that is stressed daily in developed world, through overexposure, audition. Independent external stressors, hearing deteriorates purely due to aging; a common feature all animals with auditory systems: from humans mice fish insects. Currently do not have any measure how resilience system depend on age for system. Here exploited genetically physiologically high-throughput...
Abstract Aging is due to a complex decline of multiple biological processes. Some the causes include oxidative damage, mitochondrial and proteostatic dysfunction, DNA damage. The result that as systems age their performance deteriorates. This age-related well quantified, experienced, for human hearing presumed be decrease in ear’s metabolism – specifically ability maintain an electrochemical gradient, endocochlear potential. However, direct measurements across lifespan auditory system are...