Presented herein is a copper-catalyzed

α-Fluoro-α′-aryl ketones are crucial in pharmaceuticals and agrochemicals. However, synthesizing unsymmetrical α-fluoro-α′-aryl poses regioselective challenges. This study presents a one-pot aryl-oxy-fluorination method for such fluoro-aryl ketones. Using ynamide, aryl boronic acid, F-source under Pd-catalysis, this efficiently produces wide range of valuable with potential applications. Through combination control experiments DFT studies, we proposed reaction mechanism involving situ acetic...

Here, we report a novel and unique application of special hydrophobic carbon dot (HCD) to monitor biomolecular self-assembly along with the detection metastable intermediates self-aggregates. We exploited restricted rotation S-S bond HCD synthesized from dithiosalicylic acid melamine exhibit different emission behaviors during amino acids proteins. The that exhibits blue in droplets or protein aggregates dynamically changes its red time course process. This distinct change can be visualized...

The interaction of biomolecules with cell membranes is crucial due to their important role in governing the cellular function and membrane dynamics. However, most studies predominantly focus on monomeric forms lipid membranes, leaving effects cytotoxic oligomeric self-aggregates largely unexplored. In this study, we present first evidence that intermediates diphenylalanine exert diverse influenced by phase charge. Our findings reveal fibrillar morphology facilitates formation supported...

Here, we report a novel and unique application of special hydrophobic carbon dot (HCD) to monitor biomolecular self-assembly, along with the detection metastable intermediates self-aggregates. We exploited restricted rotation S–S bond HCD synthesized from dithiosalicylic acid melamine illuminate different emission behaviors during self-assembly amino acids proteins. The that exhibits blue in droplets or protein aggregates dynamically changes its red over time course process. This distinct...

The aggregation and subsequent precipitation of gold nanoparticles (Au NPs) in the presence protein molecules restrict usefulness NPs biomedical applications. Till now, influence different properties Au (size, surface charge, coatings) proteins (surface chemical modification, folded unfolded states) pH ionic strength solution on both has been thoroughly discussed literature. However, underlying mechanistic pathways concentration-dependent are poorly understood. impact lipid corona...

Metal ions are known to strongly bind with different proteins and peptides, resulting in alteration of their physicochemical properties. In this work, we investigate the effect metal nuclear charges sizes on intrinsic blue luminescence self-assembled structures formed by aromatic amino acids, namely, phenylalanine tryptophan, using spectroscopic imaging techniques. The study reveals that fluorescence acid assemblies is influenced pH medium. a higher charge radius ratio promote clusterization...

Conventional gold nanoparticles (Au NPs) have many limitations, such as aggregation and subsequent precipitation in the medium of high ionic strength protein molecules. Furthermore, when exposed to biological fluids, form a corona, which controls different processes circulation lifetime, drug release profile, biodistribution, vivo cellular distribution. These limitations reduce functionality Au NPs targeted delivery, bioimaging, gene other biomedical applications. To circumvent these...

Cost-effective soft imprint lithography technique is used to prepare flexible thin polymeric surfaces containing a periodic arrangement of nanodimples and nanobumps sub-micron size. Using single master mold self-assembled colloidal crystal, metasurfaces with different depths heights patterns fixed pitch are possible, which makes the process inexpensive simple. These studied for their diffuse total transmission reflection spectra in visible range. The haze calculated from measurements....

In the present contribution, we investigate interactions of lipid bilayer membranes different charges and phase states with aliphatic amino acids varying charge (aspartic acid, glutamic arginine lysine) hydrophobicity (serine, leucine valine) by steady state time-resolved spectroscopic techniques, dynamic light scattering (DLS) measurements confocal imaging (CLSM). The study reveals that negatively charged such as aspartic acid interact strongly particularly stabilizing their gel phase. On...

The origin of the blue fluorescence proteins and peptides in visible region has been a subject intense debate despite several efforts. Although aromatic amino acids, namely tryptophan (Trp), tyrosine (Tyr), phenylalanine (Phe) are responsible for intrinsic luminescence peptides, underlying mechanism contributions these acids to unusual still not well resolved. In present endeavor, we show that clusterization both aliphatic on surface gold nanoparticles (Au NPs) leads clusteroluminescence,...

The coating of proteins and lipids around the surface nanoparticles is known as "protein corona" "lipid corona", respectively, which have promising biomedical applications. While protein corona formation well-known, lipid relatively new its stability yet to be explored. In present contribution, we report a novel underlying mechanism using aromatic amino acid-functionalized gold (Au-AA NPs) template by means spectroscopic (steady-state UV–visible fluorescence) imaging (CLSM, HR-TEM, AFM)...

In recent years, the underlying mechanism of formation lipid corona and its stability have begun to garner interest in nanoscience community. However, until now, very little is known about role different properties nanoparticles (NPs) (surface charge density, hydrophobicity, size) formation. Apart from physicochemical NPs, lipids remain elusive present contribution, we investigated interaction phenylalanine-functionalized gold NPs (Au-Phe NPs) with zwitterionic vesicles phase states (sol–gel...

The self-assembly of aromatic amino acids has been widely studied due to their ability form well-defined amyloid-like fibrillar structures. Herein, for the first time, we report existence different metastable intermediate states diverse morphologies, example, droplets, spheres, vesicles, flowers, and toroids, that are sequentially formed in aqueous medium during process phenylalanine presence divalent (Zn2+, Cd2+, Hg2+) trivalent (Al3+, Ga3+, In3+) metal ions having low pKa values. Due...

The underlying mechanism and the intermediates formation in self-assembly of aromatic amino acids, peptides proteins remain elusive despite numerous reports. We, for first time, report that one can modulate stability by tuning metal ions-amino acid interaction carboxybenzyl (Z)-protected phenylalanine (ZF). microscopic spectroscopic investigations reveal bivalent ions lead to fibrillar networks after a certain interval similar blank ZF, whereas trivalent develop vesicle-like which do not...

The underlying mechanism and intermediate formation in the self-assembly of aromatic amino acids, peptides, proteins remain elusive despite numerous reports. We, for first time, report that one can stabilize intermediates by tuning metal ion–amino acid interaction. Microscopic spectroscopic investigations carboxybenzyl (Z)-protected phenylalanine (ZF) reveal bivalent ions eventually lead to fibrillar networks similar blank ZF whereas trivalent develop vesicle-like do not undergo fibrillation...

Recently, buffer molecules have been known to affect intermolecular protein-protein interactions at physiological pH. However, the roles of and different monolayer protein concentrations remain elusive in controlling interaction gold nanoparticles (Au NPs) with molecules. Herein, for first time taking phenylalanine functionalized (Au-Phe lysozyme (Lyz) as model systems, we report that charges (at a particular pH) play diverse protein-Au NPs interaction, particularly induced Au aggregation....

The regioselective hydro-functionalization reaction is a powerful method to convert readily available alkynes into structurally diverse olefins.

Discriminatory emission behaviour of the H-CDs in ordered and disordered phase lipid.

A synchronous generator is forced to asynchronous operation under sudden field failure. Under such fault condition, the general practice switch off faulted machine by action of an off-set type mho-relay after appropriate time delay allow for recoverable swings. This good enough salient pole hydro-alternators which both reactive power burden and pulsating component are relatively large. But these quantities not prohibitively high a cylindrical turbo-alternator. Sustained failure may be...

A variety of analytical approaches have been developed for the study quantum spin systems in two dimensions, notable ones being spin-waves, slave boson/fermion parton constructions, and lattices with one-to-one local correspondence faces vertices, two-dimensional (2D) Jordan-Wigner (JW) fermionization. Field-theoretically, JW fermionization is implemented through Chern-Simons (CS) flux attachment. For a correct lattice spin-$1/2$ magnets, it necessary that fermions obey mutual bosonic...

Thermal Hall transport has emerged as a valuable tool for probing the fractionalized excitations in chiral quantum spin liquids. Observing quantized thermal response, expected at temperatures below spectral gap, been challenging and controversial. The finite temperature behavior, especially critical regime above can provide useful signatures of underlying topological order. In this context, we study spin-$1/2$ Heisenberg antiferromagnet on kagome lattice that is believed to be U$(1)$ Dirac...