A5093096418- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Metabolism and Genetic Disorders
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Mitochondrial Function and Pathology
- T-cell and B-cell Immunology
- Ion Transport and Channel Regulation
Radboud University Nijmegen
2019-2024
Radboud Institute for Molecular Life Sciences
2019
Radboud University Medical Center
2019
Abstract Organic anion transporters (OATs) 1 and 3 are, besides being uptake transporters, key in several cellular metabolic pathways. The underlying mechanisms are largely unknown. Hence, we used human conditionally immortalized proximal tubule epithelial cells (ciPTEC) overexpressing OAT1 or OAT3 to gain insight into these mechanisms. In ciPTEC-OAT1 -OAT3, extracellular lactate levels were decreased (by 77% 71%, respectively), while intracellular ATP remained unchanged, suggesting a shift...
Many autoimmune diseases are characterized by B cells that mistakenly recognize autoantigens and produce antibodies toward self-proteins. Current therapies aim to suppress the immune system, which is associated with adverse effects. An attractive more specific approach target autoreactive selectively through their unique B-cell receptor (BCR) using an autoantigen coupled effector molecule able modulate activity. The cellular response upon antigen binding, such as internalization, impacts...